Mannose as a driver of γδ t cell kidney infiltration

Mannose as a driver of γδ t cell kidney infiltration

Play all audios:

Loading...

Access through your institution Buy or subscribe Aberrant glycosylation has been implicated in autoimmune diseases, and high expression of mannose in the kidney might contribute to lupus


nephritis (LN) by promoting γδ T cell infiltration, according to a study by Salomé Pinho and colleagues. Ageing _Mgat5__−/−_ mice, whose kidneys are enriched in mannose structures, developed


a lupus-like syndrome spontaneously. These animals had more kidney γδ T cells than wild-type controls, and non-immune kidney cells expressed higher levels of motifs that could be recognised


by the mouse homologue of DC-SIGN. Tissue explants of _Mgat5__−/−_ mice also released more IL-17a and IFNγ compared with controls, but these effects were abrogated in TCRδ-deficient


_Mgat5__−/−_ mice. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals


Get Nature+, our best-value online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $209.00 per year only


$17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout


ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Alves, I. et al. Host-derived mannose


glycans trigger a pathogenic γδ T cell/IL-17a axis in autoimmunity. _Sci. Transl. Med._ 15, eabo1930 (2023) Article  CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION


AUTHORS AND AFFILIATIONS * Nature Reviews Nephrology http://www.nature.com/nrneph Monica Wang Authors * Monica Wang View author publications You can also search for this author inPubMed 


Google Scholar CORRESPONDING AUTHOR Correspondence to Monica Wang. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wang, M. Mannose as a driver of γδ T


cell kidney infiltration. _Nat Rev Nephrol_ 19, 359 (2023). https://doi.org/10.1038/s41581-023-00724-x Download citation * Published: 02 May 2023 * Issue Date: June 2023 * DOI:


https://doi.org/10.1038/s41581-023-00724-x SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not


currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative