Positive trials in ischaemic stroke reported at esoc 2018

Positive trials in ischaemic stroke reported at esoc 2018

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Access through your institution Buy or subscribe The WAKE-UP trial, led by Götz Thomalla and Christian Gerloff, was designed to determine whether MRI can be used to inform the acute


management of patients with an unknown time of stroke onset. Currently, these patients are ineligible for treatment with intravenous thrombolysis because guidelines recommend this treatment


only when administration within 4.5 h of known stroke onset is possible. The trial builds on previous work that showed that comparison of diffusion-weighted imaging (DWI) and fluid


attenuation inversion recovery (FLAIR) imaging can identify a recent stroke. “If there’s a mismatch between a visible ischaemic lesion on DWI but no marked hyperintensity on FLAIR imaging,


we can assume that the stroke has occurred recently and the patient is likely to benefit from thrombolysis,” Thomalla explained at the ESOC. This is a preview of subscription content, access


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SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about


institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLES * Thomalla, G. et al. MRI-guided thrombolysis for stroke with unknown time of onset. _N.


Engl. J. Med_. https://doi.org/10.1056/NEJMoa1804355 (2018) Article  PubMed  Google Scholar  * Johnston, S. C. et al. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. _N.


Engl. J. Med_. https://doi.org/10.1056/NEJMoa1800410 (2018) Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Neurology


http://www.nature.com/nrneurol/ Ian Fyfe Authors * Ian Fyfe View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Ian


Fyfe. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fyfe, I. Positive trials in ischaemic stroke reported at ESOC 2018. _Nat Rev Neurol_ 14, 379


(2018). https://doi.org/10.1038/s41582-018-0023-x Download citation * Published: 01 June 2018 * Issue Date: July 2018 * DOI: https://doi.org/10.1038/s41582-018-0023-x SHARE THIS ARTICLE


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