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Access through your institution Buy or subscribe The WAKE-UP trial, led by Götz Thomalla and Christian Gerloff, was designed to determine whether MRI can be used to inform the acute
management of patients with an unknown time of stroke onset. Currently, these patients are ineligible for treatment with intravenous thrombolysis because guidelines recommend this treatment
only when administration within 4.5 h of known stroke onset is possible. The trial builds on previous work that showed that comparison of diffusion-weighted imaging (DWI) and fluid
attenuation inversion recovery (FLAIR) imaging can identify a recent stroke. “If there’s a mismatch between a visible ischaemic lesion on DWI but no marked hyperintensity on FLAIR imaging,
we can assume that the stroke has occurred recently and the patient is likely to benefit from thrombolysis,” Thomalla explained at the ESOC. This is a preview of subscription content, access
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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLES * Thomalla, G. et al. MRI-guided thrombolysis for stroke with unknown time of onset. _N.
Engl. J. Med_. https://doi.org/10.1056/NEJMoa1804355 (2018) Article PubMed Google Scholar * Johnston, S. C. et al. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. _N.
Engl. J. Med_. https://doi.org/10.1056/NEJMoa1800410 (2018) Article Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Neurology
http://www.nature.com/nrneurol/ Ian Fyfe Authors * Ian Fyfe View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Ian
Fyfe. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fyfe, I. Positive trials in ischaemic stroke reported at ESOC 2018. _Nat Rev Neurol_ 14, 379
(2018). https://doi.org/10.1038/s41582-018-0023-x Download citation * Published: 01 June 2018 * Issue Date: July 2018 * DOI: https://doi.org/10.1038/s41582-018-0023-x SHARE THIS ARTICLE
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