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Access through your institution Buy or subscribe Interneuron progenitor cells transplanted into the hippocampus can be incorporated into neuronal circuits and improve outcomes after
traumatic brain injury (TBI) in a mouse model, according to new research published in _Nature Communications_. Bingyao Zhu and colleagues isolated inhibitory interneuron progenitors from the
medial ganglionic eminence of mouse embryos and transplanted these cells into the hippocampus in mice that had been subjected to controlled cortical impact — a mechanical model that is
thought to accurately replicate the effects of TBI in humans. The cells were shown to undergo maturation and integrate functionally into hippocampal circuits. The mice that received the
transplants showed improvements in memory precision and reductions in post-traumatic seizures, indicating restoration of inhibitory network function in the hippocampus. This is a preview of
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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Zhu, B. et al. Transplanted interneurons improve memory precision
after traumatic brain injury. _Nat. Commun._ 10, 5156 (2019) Article Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Neurology
http://www.nature.com/nrneurol/ Heather Wood Authors * Heather Wood View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence
to Heather Wood. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wood, H. Interneuron transplants elicit hippocampal repair after traumatic brain injury
in mice. _Nat Rev Neurol_ 16, 2 (2020). https://doi.org/10.1038/s41582-019-0291-0 Download citation * Published: 21 November 2019 * Issue Date: January 2020 * DOI:
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