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Access through your institution Buy or subscribe A study published in _Brain_ has found correlations between serum and cerebrospinal fluid levels of insulin-like growth factor binding
protein 2 (IGFBP2) and various measures of Alzheimer disease (AD) pathology. In a cohort of 241 individuals who were dementia-free, elevated plasma IGFBP2 was associated with an increased
rate of conversion to AD. Insulin–IGF signalling has an important role in hippocampal function; thus, the findings could provide clues to the selective vulnerability of this region in AD.
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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Quesnel, M. J. et al. Insulin-like growth factor
binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains. _Brain_ https://doi.org/10.1093/brain/awad398 (2023) Article PubMed Google Scholar Download references AUTHOR
INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Neurology http://www.nature.com/nrneurol/ Lisa Kiani Authors * Lisa Kiani View author publications You can also search for this author
inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Lisa Kiani. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kiani, L. IGFBP2 levels
associated with Alzheimer disease. _Nat Rev Neurol_ 20, 1 (2024). https://doi.org/10.1038/s41582-023-00911-1 Download citation * Published: 04 December 2023 * Issue Date: January 2024 * DOI:
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