The (orf)ull truth about irf5 and type i interferons in sle

The (orf)ull truth about irf5 and type i interferons in sle

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Exactly how nucleic acids trigger type I interferon responses via certain Toll-like receptors has been uncertain. Now, a new pathway involving gene products previously linked to systemic


lupus erythematosus but not known to interact has been unravelled, which could be of relevance to the female sex bias in this disease. Access through your institution Buy or subscribe This


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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Odhams, C. A. et al. Interferon inducible X-linked gene _CXorf21_


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_Immunity_ 41, 375–388 (2014). Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS The authors thank Jie An and Gillian I. Rice for helpful discussions. The work of the


authors is supported by grants from the National Institutes of Health, Lupus Research Alliance and Rheumatology Research Foundation (to K.B.E.) and the Medical Research Foundation and the


NIHR Manchester Biomedical Research Centre (to T.B.). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. AUTHOR


INFORMATION AUTHORS AND AFFILIATIONS * Departments of Medicine and Immunology, University of Washington, Seattle, WA, USA Keith B. Elkon * NW Genomic Laboratory Hub, Manchester Centre for


Genomic Medicine, St Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester, UK Tracy A. Briggs * Division of Evolution and Genomic Sciences, School of Biological Sciences,


University of Manchester, Manchester, UK Tracy A. Briggs Authors * Keith B. Elkon View author publications You can also search for this author inPubMed Google Scholar * Tracy A. Briggs View


author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Keith B. Elkon or Tracy A. Briggs. ETHICS DECLARATIONS COMPETING


INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Elkon, K.B., Briggs, T.A. The (Orf)ull truth about


IRF5 and type I interferons in SLE. _Nat Rev Rheumatol_ 16, 543–544 (2020). https://doi.org/10.1038/s41584-020-0472-7 Download citation * Published: 24 July 2020 * Issue Date: October 2020 *


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