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Exactly how nucleic acids trigger type I interferon responses via certain Toll-like receptors has been uncertain. Now, a new pathway involving gene products previously linked to systemic
lupus erythematosus but not known to interact has been unravelled, which could be of relevance to the female sex bias in this disease. Access through your institution Buy or subscribe This
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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Odhams, C. A. et al. Interferon inducible X-linked gene _CXorf21_
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_Immunity_ 41, 375–388 (2014). Article CAS Google Scholar Download references ACKNOWLEDGEMENTS The authors thank Jie An and Gillian I. Rice for helpful discussions. The work of the
authors is supported by grants from the National Institutes of Health, Lupus Research Alliance and Rheumatology Research Foundation (to K.B.E.) and the Medical Research Foundation and the
NIHR Manchester Biomedical Research Centre (to T.B.). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. AUTHOR
INFORMATION AUTHORS AND AFFILIATIONS * Departments of Medicine and Immunology, University of Washington, Seattle, WA, USA Keith B. Elkon * NW Genomic Laboratory Hub, Manchester Centre for
Genomic Medicine, St Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester, UK Tracy A. Briggs * Division of Evolution and Genomic Sciences, School of Biological Sciences,
University of Manchester, Manchester, UK Tracy A. Briggs Authors * Keith B. Elkon View author publications You can also search for this author inPubMed Google Scholar * Tracy A. Briggs View
author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Keith B. Elkon or Tracy A. Briggs. ETHICS DECLARATIONS COMPETING
INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Elkon, K.B., Briggs, T.A. The (Orf)ull truth about
IRF5 and type I interferons in SLE. _Nat Rev Rheumatol_ 16, 543–544 (2020). https://doi.org/10.1038/s41584-020-0472-7 Download citation * Published: 24 July 2020 * Issue Date: October 2020 *
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