Early diagnosis of immune-mediated arthropathies is important for early and effective treatment, but often relies on clinical expertise. Can the use of a new genetic risk score help rule out

and prioritize certain diagnoses? And does this score add any clinical utility to current clinical diagnostic pathways? Access through your institution Buy or subscribe This is a preview of

subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value

online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more

outpatients with inflammatory arthritis. _Sci. Transl Med._ 12, eaay1548 (2020). Article  Google Scholar  * Parkes, M., Cortes, A., van Heel, D. A. & Brown, M. A. Genetic insights into

common pathways and complex relationships among immune-mediated diseases. _Nat. Rev. Genet._ 14, 661–673 (2013). Article  CAS  Google Scholar  * Rudwaleit, M., van der Heijde, D., Khan, M.

A., Braun, J. & Sieper, J. How to diagnose axial spondyloarthritis early. _Ann. Rheum. Dis._ 63, 535–543 (2004). Article  CAS  Google Scholar  * Shovman, O. et al. The diagnostic utility

of anti-cyclic citrullinated peptide antibodies, matrix metalloproteinase-3, rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein in patients with erosive and

non-erosive rheumatoid arthritis. _Clin. Dev. Immunol._ 12, 197–202 (2005). Article  CAS  Google Scholar  * Thomas, G. P. et al. Genetic diagnostic profiling in axial spondyloarthritis: a

real world study. _Clin. Exp. Rheumatol._ 35, 229–233 (2017). PubMed  Google Scholar  * Wood, A. R. et al. Defining the role of common variation in the genomic and biological architecture of

adult human height. _Nat. Genet._ 46, 1173–1186 (2014). Article  CAS  Google Scholar  * Li, Z. et al. Genetic risk score prediction in ankylosing spondylitis. _Arthritis Rheum._ 70, 1–3553

(2018). CAS  Google Scholar  * Stuart, P. E. et al. Genome-wide association analysis of psoriatic arthritis and cutaneous psoriasis reveals differences in their genetic architecture. _Am. J.

Hum. Genet._ 97, 816–883 (2015). Article  CAS  Google Scholar  * Ge, T., Chen, C. Y., Ni, Y., Feng, Y. A. & Smoller, J. W. Polygenic prediction via Bayesian regression and continuous

shrinkage priors. _Nat. Commun._ 10, 1776 (2019). Article  Google Scholar  * Rostami, S. et al. Prediction of ankylosing spondylitis in the population-based HUNT study by a genetic risk

score combining 110 SNPs of genome-wide significance. _J. Rheumatol._ 47, 204–210 (2020). Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Guy’s

& St Thomas’ NHS Foundation Trust and King’s College London NIHR Biomedical Research Centre, London, England Matthew A. Brown * Division of Rheumatology, Department of Medicine 3,

Medical University of Vienna, Vienna, Austria Daniel Aletaha Authors * Matthew A. Brown View author publications You can also search for this author inPubMed Google Scholar * Daniel Aletaha

View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Matthew A. Brown. ETHICS DECLARATIONS COMPETING INTERESTS The

authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Brown, M.A., Aletaha, D. Genetic risk scores in inflammatory

arthritis: a new era?. _Nat Rev Rheumatol_ 16, 545–546 (2020). https://doi.org/10.1038/s41584-020-0473-6 Download citation * Published: 20 July 2020 * Issue Date: October 2020 * DOI:

https://doi.org/10.1038/s41584-020-0473-6 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative