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Access through your institution Buy or subscribe In rheumatoid arthritis (RA), recurring bouts of inflammation (known as disease flares) often occur at sites previously affected by disease.
Emerging evidence implicates ‘inflammatory tissue priming’ (which sensitizes tissue to further episodes of inflammation) in this process. New findings show that inhibition of epigenetic
processes in synovial fibroblasts can reverse inflammatory priming and prevent flares in experimental models of arthritis. Building on these findings, the investigators looked at the effects
of a pan-BET inhibitor — I-BET151 — in an experimental model of arthritis involving repeated injection of an inflammatory trigger (monosodium urate crystals or zymosan) into the mouse paw.
Although treatment with I-BET151 had no effect on the first bout of arthritis, this inhibitor reduced the severity of subsequent arthritis flares. This effect occurred irrespective of
whether the inhibitor was given systemically or locally, or in a preventive or therapeutic treatment setting. This is a preview of subscription content, access via your institution ACCESS
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FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Friščić, J. et al. Reset of inflammatory priming of joint tissue and reduction of the severity of arthritis flares by
bromodomain inhibition. _Arthritis Rheumatol._ https://doi.org/10.1002/art.42378 (2022) Article Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature
Reviews Rheumatology http://www.nature.com/nrrheum/ Jessica McHugh Authors * Jessica McHugh View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING
AUTHOR Correspondence to Jessica McHugh. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McHugh, J. Reversal of inflammatory priming prevents arthritic
flares. _Nat Rev Rheumatol_ 19, 2 (2023). https://doi.org/10.1038/s41584-022-00881-6 Download citation * Published: 30 November 2022 * Issue Date: January 2023 * DOI:
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