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Access through your institution Buy or subscribe The ability of stem cells to enhance osseointegration (bone ingrowth into an implant) in joint replacement for rheumatoid arthritis (RA) is
limited by the presence of reactive oxygen species (ROS) and a lack of oxygen. Researchers have now developed an ROS-scavenging, oxygen-producing hydrogel as a protective delivery vehicle
for bone-marrow-derived mesenchymal stem cells (BMSCs). Articular damage in RA can necessitate joint replacement. BMSCs can potentially improve the outcomes of this therapy, but the survival
of transplanted BMSCs is compromised by the hostile joint microenvironment. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
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REFERENCES ORIGINAL ARTICLE * Zhao, Y. et al. Nanozyme-reinforced hydrogel as a H2O2-driven oxygenerator for enhancing prosthetic interface osseointegration in rheumatoid arthritis therapy.
_Nat. Commun._ 13, 6758 (2022) Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology http://www.nature.com/nrrheum/
Robert Phillips Authors * Robert Phillips View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Robert Phillips. RIGHTS
AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Phillips, R. Hypoxia-modifying hydrogel supports stem cells for joint repair. _Nat Rev Rheumatol_ 19, 62 (2023).
https://doi.org/10.1038/s41584-022-00895-0 Download citation * Published: 21 December 2022 * Issue Date: February 2023 * DOI: https://doi.org/10.1038/s41584-022-00895-0 SHARE THIS ARTICLE
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