Author correction: a naturally occurring antiviral ribonucleotide encoded by the human genome

Author correction: a naturally occurring antiviral ribonucleotide encoded by the human genome

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Correction to: _Nature_ https://doi.org/10.1038/s41586-018-0238-4Published online 20 June 2018 In this Letter, the isotopologue used to demonstrate hydrogen atom abstraction from CTP was incorrectly identified as 2′,3′,4′,5′,5-deutero-CTP, whereas the isotopologue we used was 3′,4′,5′,5-deutero-CTP. (Boldface indicates where changes were made.) In the main text, the sentence “Incubation of rVIP with SAM and CTP deuterated at the 2′, 3′, 4′, 5′ and 5 positions (deuCTP), increased the −_m_/_z_ of 5ʹ-dA from 250.1 to 251.1, consistent with the transfer of one deuterium from deuCTP to 5ʹ-dA.” should have read “Incubation of rVIP with SAM and CTP deuterated at the 3′, 4′, 5′ and 5 positions (deuCTP) increased the −_m_/_z_ of 5ʹ-dA from 250.1 to 251.1, consistent with the transfer of one deuterium from deuCTP to 5ʹ-dA.”. In the Extended Data Fig. 3 legend the sentence “When rVIP was incubated with SAM and CTP deuterated at the 2′, 3′, 4′, 5′ and 5 positions (deuCTP), the −_m_/_z_ of 5′-dA increased from 250.1 to 251.1, consistent with the transfer of one deuterium from deuCTP to 5′-dA•.” should have read: “When rVIP was incubated with SAM and CTP deuterated at the 3′, 4′, 5′ and 5 positions (deuCTP), the −_m_/_z_ of 5′-dA increased from 250.1 to 251.1, consistent with the transfer of one deuterium from deuCTP to 5′-dA•.” Similarly, the name of the isotopologue appeared incorrectly in the Supplementary Information. In the Supplementary Information section ‘Hydrogen atom abstraction specificity’ the sentence “Reactions of 100 μL total volume contained 100 μM rVIP, 50 mM HEPES pH 7.5, 150 mM KCl, 1 mM SAM, and 1 mM deuterium-labeled CTP (site-specifically labeled CTP contains deuterium at the following positioN; (2'-2H, 3'-2H, 4'-2H, or 5'-2H2-CTP)).” should have read: "Reactions of 100 μL total volume contained 100 μM rVIP, 50 mM HEPES pH 7.5, 150 mM KCl, 1 mM SAM, and 1 mM deuterium-labelled CTP (site-specifically labelled CTP contains deuterium at the following positions: 3'-2H,4'-2H,5'-2H2,5-2H-CTP or 2'-2H-CTP,3'-2H-CTP,4'-2H-CTP or 5'-2H2-CTP). In the Supplementary Information section ‘2'-deoxy-CTP vs deutero-CTP substrate specificity assays’ the sentence “Reactions of 100 μL total volume contained 100 μM rVIP, 50 mM HEPES pH 7.5, 150 mM KCl, 1 mM SAM, 1 mM deutero-CTP (2'-2H, 3'-2H, 4'-2H, 5'-2H2, AND 5-2H –CTP), and unlabeled 1 mM 2'-deoxy-CTP.” should have read: “Reactions of 100 μL total volume contained 100 μM rVIP, 50 mM HEPES pH 7.5, 150 mM KCl, 1 mM SAM, 1 mM deutero-CTP (3'-2H,4'-2H,5'-2H2,5-2H-CTP), and unlabelled 1 mM 2'-deoxy-CTP.” These errors have been corrected online. AUTHOR INFORMATION Author notes * These authors contributed equally: Anthony S. Gizzi, Tyler L. Grove AUTHORS AND AFFILIATIONS * Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA Anthony S. Gizzi, Tyler L. Grove, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, Anne R. Bresnick & Steven C. Almo * Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA Jamie J. Arnold, Joyce Jose & Craig E. Cameron * Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA Rohit K. Jangra & Kartik Chandran * Institute for Protein Innovation, Boston, MA, USA James D. Love & Steven C. Almo Authors * Anthony S. Gizzi View author publications You can also search for this author inPubMed Google Scholar * Tyler L. Grove View author publications You can also search for this author inPubMed Google Scholar * Jamie J. Arnold View author publications You can also search for this author inPubMed Google Scholar * Joyce Jose View author publications You can also search for this author inPubMed Google Scholar * Rohit K. Jangra View author publications You can also search for this author inPubMed Google Scholar * Scott J. Garforth View author publications You can also search for this author inPubMed Google Scholar * Quan Du View author publications You can also search for this author inPubMed Google Scholar * Sean M. Cahill View author publications You can also search for this author inPubMed Google Scholar * Natalya G. Dulyaninova View author publications You can also search for this author inPubMed Google Scholar * James D. Love View author publications You can also search for this author inPubMed Google Scholar * Kartik Chandran View author publications You can also search for this author inPubMed Google Scholar * Anne R. Bresnick View author publications You can also search for this author inPubMed Google Scholar * Craig E. Cameron View author publications You can also search for this author inPubMed Google Scholar * Steven C. Almo View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Steven C. Almo. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Gizzi, A.S., Grove, T.L., Arnold, J.J. _et al._ Author Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome. _Nature_ 583, E15 (2020). https://doi.org/10.1038/s41586-020-2322-9 Download citation * Published: 16 June 2020 * Issue Date: 02 July 2020 * DOI: https://doi.org/10.1038/s41586-020-2322-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

Correction to: _Nature_ https://doi.org/10.1038/s41586-018-0238-4Published online 20 June 2018 In this Letter, the isotopologue used to demonstrate hydrogen atom abstraction from CTP was


incorrectly identified as 2′,3′,4′,5′,5-deutero-CTP, whereas the isotopologue we used was 3′,4′,5′,5-deutero-CTP. (Boldface indicates where changes were made.) In the main text, the sentence


“Incubation of rVIP with SAM and CTP deuterated at the 2′, 3′, 4′, 5′ and 5 positions (deuCTP), increased the −_m_/_z_ of 5ʹ-dA from 250.1 to 251.1, consistent with the transfer of one


deuterium from deuCTP to 5ʹ-dA.” should have read “Incubation of rVIP with SAM and CTP deuterated at the 3′, 4′, 5′ and 5 positions (deuCTP) increased the −_m_/_z_ of 5ʹ-dA from 250.1 to


251.1, consistent with the transfer of one deuterium from deuCTP to 5ʹ-dA.”. In the Extended Data Fig. 3 legend the sentence “When rVIP was incubated with SAM and CTP deuterated at the 2′,


3′, 4′, 5′ and 5 positions (deuCTP), the −_m_/_z_ of 5′-dA increased from 250.1 to 251.1, consistent with the transfer of one deuterium from deuCTP to 5′-dA•.” should have read: “When rVIP


was incubated with SAM and CTP deuterated at the 3′, 4′, 5′ and 5 positions (deuCTP), the −_m_/_z_ of 5′-dA increased from 250.1 to 251.1, consistent with the transfer of one deuterium from


deuCTP to 5′-dA•.” Similarly, the name of the isotopologue appeared incorrectly in the Supplementary Information. In the Supplementary Information section ‘Hydrogen atom abstraction


specificity’ the sentence “Reactions of 100 μL total volume contained 100 μM rVIP, 50 mM HEPES pH 7.5, 150 mM KCl, 1 mM SAM, and 1 mM deuterium-labeled CTP (site-specifically labeled CTP


contains deuterium at the following positioN; (2'-2H, 3'-2H, 4'-2H, or 5'-2H2-CTP)).” should have read: "Reactions of 100 μL total volume contained 100 μM rVIP, 50


mM HEPES pH 7.5, 150 mM KCl, 1 mM SAM, and 1 mM deuterium-labelled CTP (site-specifically labelled CTP contains deuterium at the following positions:


3'-2H,4'-2H,5'-2H2,5-2H-CTP or 2'-2H-CTP,3'-2H-CTP,4'-2H-CTP or 5'-2H2-CTP). In the Supplementary Information section ‘2'-deoxy-CTP vs deutero-CTP


substrate specificity assays’ the sentence “Reactions of 100 μL total volume contained 100 μM rVIP, 50 mM HEPES pH 7.5, 150 mM KCl, 1 mM SAM, 1 mM deutero-CTP (2'-2H, 3'-2H,


4'-2H, 5'-2H2, AND 5-2H –CTP), and unlabeled 1 mM 2'-deoxy-CTP.” should have read: “Reactions of 100 μL total volume contained 100 μM rVIP, 50 mM HEPES pH 7.5, 150 mM KCl, 1


mM SAM, 1 mM deutero-CTP (3'-2H,4'-2H,5'-2H2,5-2H-CTP), and unlabelled 1 mM 2'-deoxy-CTP.” These errors have been corrected online. AUTHOR INFORMATION Author notes *


These authors contributed equally: Anthony S. Gizzi, Tyler L. Grove AUTHORS AND AFFILIATIONS * Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA Anthony S.


Gizzi, Tyler L. Grove, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, Anne R. Bresnick & Steven C. Almo * Department of Biochemistry and Molecular Biology, The


Pennsylvania State University, University Park, PA, USA Jamie J. Arnold, Joyce Jose & Craig E. Cameron * Department of Microbiology and Immunology, Albert Einstein College of Medicine,


Bronx, NY, USA Rohit K. Jangra & Kartik Chandran * Institute for Protein Innovation, Boston, MA, USA James D. Love & Steven C. Almo Authors * Anthony S. Gizzi View author


publications You can also search for this author inPubMed Google Scholar * Tyler L. Grove View author publications You can also search for this author inPubMed Google Scholar * Jamie J.


Arnold View author publications You can also search for this author inPubMed Google Scholar * Joyce Jose View author publications You can also search for this author inPubMed Google Scholar


* Rohit K. Jangra View author publications You can also search for this author inPubMed Google Scholar * Scott J. Garforth View author publications You can also search for this author


inPubMed Google Scholar * Quan Du View author publications You can also search for this author inPubMed Google Scholar * Sean M. Cahill View author publications You can also search for this


author inPubMed Google Scholar * Natalya G. Dulyaninova View author publications You can also search for this author inPubMed Google Scholar * James D. Love View author publications You can


also search for this author inPubMed Google Scholar * Kartik Chandran View author publications You can also search for this author inPubMed Google Scholar * Anne R. Bresnick View author


publications You can also search for this author inPubMed Google Scholar * Craig E. Cameron View author publications You can also search for this author inPubMed Google Scholar * Steven C.


Almo View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Steven C. Almo. RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Gizzi, A.S., Grove, T.L., Arnold, J.J. _et al._ Author Correction: A naturally occurring antiviral ribonucleotide encoded by the human


genome. _Nature_ 583, E15 (2020). https://doi.org/10.1038/s41586-020-2322-9 Download citation * Published: 16 June 2020 * Issue Date: 02 July 2020 * DOI:


https://doi.org/10.1038/s41586-020-2322-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not


currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative