Play all audios:
An analysis of somatic mutations in blood exomes from 200,618 individuals revealed previously unrecognized genes driving clonal hematopoiesis. Mutations in these genes showed age-dependent
clonal expansion and their presence correlated with heightened risks of infection, death and hematological malignancy. Access through your institution Buy or subscribe This is a preview of
subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value
online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more
Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS:
* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Zink, F. et al. Clonal hematopoiesis, with and without candidate driver mutations,
is common in the elderly. _Blood_ 130, 742–752 (2017). THIS PAPER FIRST REPORTED THAT A SUBSTANTIAL FRACTION OF CLONAL HEMATOPOIESIS LACKS KNOWN DRIVERS. Article CAS PubMed PubMed Central
Google Scholar * Mitchell, E. et al. Clonal dynamics of haematopoiesis across the human lifespan. _Nature_ 606, 343–350 (2022). THIS PAPER IDENTIFIED ‘DRIVERLESS’ CLONAL EXPANSIONS IN
PARALLEL TO CLONES WITH DRIVERS IN HEALTHY AGING BLOOD. Article CAS PubMed PubMed Central Google Scholar * Bick, A. G. et al. Inherited causes of clonal haematopoiesis in 97,691 whole
genomes. _Nature_ 586, 763–768 (2020). THIS PAPER REPORTS ON A CANONICAL SET OF DRIVERS OF CLONAL HEMATOPOIESIS. Article CAS PubMed PubMed Central Google Scholar * Jaiswal, S. et al.
Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease. _N. Engl. J. Med._ 377, 111–121 (2017). THIS PAPER REPORTS ON A CANONICAL SET OF DRIVERS OF CLONAL HEMATOPOIESIS.
Article PubMed PubMed Central Google Scholar * Pich, O. et al. Discovering the drivers of clonal hematopoiesis. _Nat. Commun._ 13, 4267 (2022). THIS PAPER REPORTS ON ADDITIONAL CANDIDATE
DRIVERS OF CLONAL HEMATOPOIESIS BY LOOKING FOR SIGNALS OF POSITIVE SELECTION. Article CAS PubMed PubMed Central Google Scholar Download references ADDITIONAL INFORMATION PUBLISHER’S
NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: Bernstein, N. et al. Analysis of somatic
mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis. _Nat. Genet_. https://doi.org/10.1038/s41588-024-01755-1
(2024). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Novel somatic mutations in blood driving age-related clonal hematopoiesis. _Nat Genet_ 56,
1049–1050 (2024). https://doi.org/10.1038/s41588-024-01756-0 Download citation * Published: 28 May 2024 * Issue Date: June 2024 * DOI: https://doi.org/10.1038/s41588-024-01756-0 SHARE THIS
ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard
Provided by the Springer Nature SharedIt content-sharing initiative