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Regulated destruction of proteins underlies just about everything a cell does. A structural study of human Gid4, the N-recognin of the Pro/N-end rule pathway that targets proteins through
their N-terminal proline, illuminates the recognition of substrates by this proteolytic system. Access through your institution Buy or subscribe This is a preview of subscription content,
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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Varshavsky, A. _Trends Biochem. Sci._ 30, 283–286 (2005). Article CAS Google
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Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia David A. Dougan * Division of
Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA Alexander Varshavsky Authors * David A. Dougan View author publications You can also search for this
author inPubMed Google Scholar * Alexander Varshavsky View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to David A.
Dougan or Alexander Varshavsky. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE
THIS ARTICLE Dougan, D.A., Varshavsky, A. Understanding the Pro/N-end rule pathway. _Nat Chem Biol_ 14, 415–416 (2018). https://doi.org/10.1038/s41589-018-0045-0 Download citation *
Published: 16 April 2018 * Issue Date: May 2018 * DOI: https://doi.org/10.1038/s41589-018-0045-0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this
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