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A new report shows that upregulation of the receptor TREM1 on macrophages and neutrophils, dependent on the adrenergic nervous system, links stroke to systemic inflammation and gut barrier
dysfunction, which result in bacterial translocation and exacerbation of neurological damage. Access through your institution Buy or subscribe This is a preview of subscription content,
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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Liu, Q. et al. _Nat. Immunol_. https://doi.org/10.1038/s41590-019-0421-2 (2019). * Owens, R. et al.
_Front. Cell. Neurosci._ 11, 56 (2017). PubMed PubMed Central Google Scholar * Keren-Shaul, H. et al. _Cell_ 169, 1276–1290.e17 (2017). Article CAS Google Scholar * Huang, J. et al.
_Science_ 285, 595–599 (1999). Article CAS Google Scholar * Joy, M. T. et al. _Cell_ 176, 1143–1157.e13 (2019). Article CAS Google Scholar * Jolly, L. et al. _Cardiovasc. Res._ 114,
907–918 (2018). Article CAS Google Scholar * Szigeti, K. et al. _J. Cereb. Blood Flow Metab._ 35, 1921–1929 (2015). Article Google Scholar * Stanley, D. et al. _Nat. Med._ 22, 1277–1284
(2016). Article CAS Google Scholar * Cuvier, V. et al. _Br. J. Clin. Pharmacol._ 84, 2270–2279 (2018). Article CAS Google Scholar * Rasid, O. & Cavaillon, J. M. _Microbes Infect._
20, 156–165 (2018). Article CAS Google Scholar * Raggi, F. et al. _Front. Immunol._ 8, 1097 (2017). Article Google Scholar * Flierl, M. A. et al. _Nature_ 449, 721–725 (2007). Article
CAS Google Scholar * Weber, B. et al. _PLoS Pathog._ 10, e1003900 (2014). Article Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * German Center for
Neurodegenerative Diseases (DZNE)-Ulm, Ulm, Germany Francesco Roselli * Neurozentrum Ulm, Ulm, Germany Francesco Roselli * Institute of Clinical and Experimental Trauma Immunology, Ulm
University Hospital Ulm, Ulm, Germany Markus Huber-Lang Authors * Francesco Roselli View author publications You can also search for this author inPubMed Google Scholar * Markus Huber-Lang
View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Markus Huber-Lang. ETHICS DECLARATIONS COMPETING INTERESTS The
authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Roselli, F., Huber-Lang, M. TREM1-ors shake the brain and gut
after stroke. _Nat Immunol_ 20, 950–952 (2019). https://doi.org/10.1038/s41590-019-0443-9 Download citation * Published: 08 July 2019 * Issue Date: August 2019 * DOI:
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