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An engineered fusion protein exploits the efferocytosis pathway to clear amyloid-β (Aβ) from the brain without eliciting the severe inflammatory adverse effects associated with Aβ-targeting
antibody-based immunotherapies. In mouse models of Alzheimer’s disease, this approach induced robust clearance of Aβ without inflammation, improved synapse protection, and decreased brain
microhemorrhage, which result in superior behavioral recovery. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS
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FAQs * Contact customer support REFERENCES * Busche, M. A. & Hyman, B. T. Synergy between amyloid-beta and tau in Alzheimer’s disease. _Nat. Neurosci._ 23, 1183–1193 (2020). A REVIEW
ARTICLE THAT PRESENTS THE COMPLEX INTERACTION BETWEEN AΒ AND TAU IN AD PATHOGENESIS. Article CAS Google Scholar * Sevigny, J. et al. The antibody aducanumab reduces Abeta plaques in
Alzheimer’s disease. _Nature_ 537, 50–56 (2016). A PAPER THAT REPORTS THE EFFICACY AND SAFETY DATA FROM A PHASE 1B RANDOMIZED TRIAL OF ADUCANUMAB. Article CAS Google Scholar * Fuller, J.
P., Stavenhagen, J. B. & Teeling, J. L. New roles for Fc receptors in neurodegeneration—the impact on immunotherapy for Alzheimer’s disease. _Front. Neurosci._ 8, 235 (2014). A REVIEW
ARTICLE THAT SUGGESTS THAT ACTIVATION OF INFLAMMATORY FCRS IN THE CENTRAL NERVOUS SYSTEM MAY HAVE HARMFUL CONSEQUENCES. Article Google Scholar * Doran, A. C., Yurdagul, A. Jr. & Tabas,
I. Efferocytosis in health and disease. _Nat. Rev. Immunol._ 20, 254–267 (2020). A REVIEW ARTICLE THAT PRESENTS HOW PHAGOCYTES TAKE UP AND PROCESS APOPTOTIC CELLS. Article CAS Google
Scholar * Lemke, G. Biology of the TAM receptors. _Cold Spring Harb. Perspect. Biol._ 5, a009076 (2013). A REVIEW ARTICLE THAT PRESENTS HOW TAM RECEPTOR–LIGAND SIGNALING CONTROLS THE INNATE
IMMUNE RESPONSE. Article Google Scholar Download references ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps
and institutional affiliations. THIS IS A SUMMARY OF: Jung, H. et al. Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein. _Nat. Med_.
https://doi.org/10.1038/s41591-022-01926-9 (2022). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Toward inflammation-free therapeutics in Alzheimer’s
disease. _Nat Med_ 28, 1765–1766 (2022). https://doi.org/10.1038/s41591-022-01972-3 Download citation * Published: 08 September 2022 * Issue Date: September 2022 * DOI:
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