Capturing prime editor off-target sites within the genome

Capturing prime editor off-target sites within the genome

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Prime editing systems hold tremendous promise for the precise correction of pathogenic mutations. We developed a method to tag sequences modified by a prime editor to evaluate its


genome-wide precision for therapeutic applications. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS


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Contact customer support REFERENCES * Anzalone, A. V. et al. Search-and-replace genome editing without double-strand breaks or donor DNA. _Nature_ 576, 149–157 (2019). THIS PAPER IS THE


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ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: Liang,


S.-Q. et al. Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag. _Nat. Methods_ https://doi.org/10.1038/s41592-023-01859-2 (2023) RIGHTS AND PERMISSIONS


Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Capturing prime editor off-target sites within the genome. _Nat Methods_ 20, 801–802 (2023).


https://doi.org/10.1038/s41592-023-01860-9 Download citation * Published: 08 May 2023 * Issue Date: June 2023 * DOI: https://doi.org/10.1038/s41592-023-01860-9 SHARE THIS ARTICLE Anyone you


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