ABSTRACT Interest in deciphering the fundamental mechanisms and processes of the human mind represents a central driving force in modern neuroscience research. Activities in support of this

goal rely on advanced methodologies and engineering systems that are capable of interrogating and stimulating neural pathways, from single cells in small networks to interconnections that

span the entire brain. Recent research establishes the foundations for a broad range of creative neurotechnologies that enable unique modes of operation in this context. This review focuses

on those systems with proven utility in animal model studies and with levels of technical maturity that suggest a potential for broad deployment to the neuroscience community in the

illustrate their practical value. The vibrancy of the engineering science associated with these platforms, the interdisciplinary nature of this field of research and its relevance to grand

challenges in the treatment of neurological disorders motivate continued growth of this area of study. Access through your institution Buy or subscribe This is a preview of subscription

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS TIME FOR NANONEURO Article 18 October 2021 NANOMATERIAL-BASED

MICROELECTRODE ARRAYS FOR IN VITRO BIDIRECTIONAL BRAIN–COMPUTER INTERFACES: A REVIEW Article Open access 30 January 2023 TRANSLATION OF NEUROTECHNOLOGIES Article 31 May 2024 CHANGE HISTORY *

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Scholar  Download references ACKNOWLEDGEMENTS This research was supported by the Querrey Simpson Institute for Bioelectronics at Northwestern University. AUTHOR INFORMATION Author notes *

These authors contributed equally: Abraham Vázquez-Guardado, Yiyuan Yang, Amay J. Bandodkar. AUTHORS AND AFFILIATIONS * Center for Bio-Integrated Electronics, Northwestern University,

Evanston, IL, USA Abraham Vázquez-Guardado, Amay J. Bandodkar & John A. Rogers * Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA Yiyuan Yang & John

A. Rogers * Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA Amay J. Bandodkar & John A. Rogers * Department of Biomedical Engineering,

Northwestern University, Evanston, IL, USA John A. Rogers * Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, USA John A. Rogers * Querrey

Simpson Institute for Bioelectronics, Northwestern University, Chicago, IL, USA John A. Rogers * Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University,

Chicago, IL, USA John A. Rogers Authors * Abraham Vázquez-Guardado View author publications You can also search for this author inPubMed Google Scholar * Yiyuan Yang View author publications

You can also search for this author inPubMed Google Scholar * Amay J. Bandodkar View author publications You can also search for this author inPubMed Google Scholar * John A. Rogers View

author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS A.V.-G., Y.Y., A.J.B., and J.A.R. cowrote and co-edited the manuscript. CORRESPONDING AUTHOR

Correspondence to John A. Rogers. ETHICS DECLARATIONS COMPETING INTERESTS J.A.R. is cofounder in a company, Neurolux Inc., that offers related technology products to the neuroscience

community. ADDITIONAL INFORMATION PEER REVIEW INFORMATION Nature Neuroscience thanks Sebastian Haesler and the other, anonymous, reviewer(s) for their contribution to the peer review of this

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ABOUT THIS ARTICLE CITE THIS ARTICLE Vázquez-Guardado, A., Yang, Y., Bandodkar, A.J. _et al._ Recent advances in neurotechnologies with broad potential for neuroscience research. _Nat

Neurosci_ 23, 1522–1536 (2020). https://doi.org/10.1038/s41593-020-00739-8 Download citation * Received: 26 June 2020 * Accepted: 09 October 2020 * Published: 16 November 2020 * Issue Date:

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