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A genetic variant specific to people of African ancestry increases the risk of neurodegenerative diseases, such as Parkinson disease (PD). This variant occurs in a noncoding region and
interferes with the splicing of mRNA transcripts, resulting in lowered protein levels and activity. This work reveals a novel therapeutic target in an underserved and underrepresented
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local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Rizig,
M. et al. Identification of genetic risk loci and causal insights associated with Parkinson’s disease in African and African admixed populations: a genome-wide association study. _Lancet
Neurol._ 22, 1015–1025 (2023). THIS PAPER REPORTS RS3115534-G AS A NEURODEGENERATION RISK VARIANT IN POPULATIONS OF AFRICAN ANCESTRY. Article CAS PubMed PubMed Central Google Scholar *
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Neurol._ 70, 727–735 (2013). THIS PAPER ANALYZES _GBA1_ CODING MUTATIONS AND THEIR RISK FOR DEMENTIA WITH LEWY BODIES. Article PubMed Google Scholar * Global Parkinson’s Genetics Program.
GP2: The Global Parkinson’s Genetics Program. _Mov. Disord._ 36, 842–851 (2021). A PAPER THAT INTRODUCES THE GLOBAL PARKINSON’S GENETICS PROGRAM, WHICH AIMS TO FILL DIVERSITY GAPS IN
GENETIC RESEARCH. Article Google Scholar Download references ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps
and institutional affiliations. THIS IS A SUMMARY OF: Álvarez Jerez, P. et al. African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in _GBA1_. _Nat. Struct. Mol.
Biol_. https://doi.org/10.1038/s41594-024-01423-2 (2024). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Intronic variant increases Parkinson disease
risk by disrupting branchpoint sequence. _Nat Struct Mol Biol_ 32, 12–13 (2025). https://doi.org/10.1038/s41594-024-01424-1 Download citation * Published: 02 January 2025 * Issue Date:
January 2025 * DOI: https://doi.org/10.1038/s41594-024-01424-1 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
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