Author correction: mebendazole augments sensitivity to sorafenib by targeting mapk and bcl-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma

Author correction: mebendazole augments sensitivity to sorafenib by targeting mapk and bcl-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma

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Correction to: _Scientific Reports_ https://doi.org/10.1038/s41598-019-55666-x, published online 13 December 2019 The original version of this Article contained errors. The P-values for the


comparisons shown in Figure 10 and reported in the text were not controlled for alpha error. We used Hochberg’s method (the modified Bonferroni method) for P-value correction; the main


results remain the same after this correction, but the Article now reports adjusted P-values. The Article changed as follows. The original Figure 10 and accompanying legend appear below. In


the Methods, under the subheading ‘Statistical analysis’, “With regards to survival probability, a log rank (Mantel–Cox) test was performed to assess the significance of differences between


groups in Kaplan–Meier analysis. A value of P < 0.05 was considered to indicate statistical significance.” now reads: “With regards to survival probability, a log rank (Mantel–Cox) test


was performed to assess the significance of differences between groups in Kaplan–Meier analysis. A value of P < 0.05 was considered to indicate statistical significance. The P-values were


adjusted using the Hochberg's method.” In the Results, under the subheading ‘Effect on survival probability’, “The Kaplan–Meier survival curves depicted in Fig. 10 reveal that


DEN-treated model mice had higher mortality rates than MBZ-treated HCC mice (log-rank test P = 0.04, hazard ratio = 2.03) (Fig. 10b), SO-treated HCC mice (log-rank test P = 0.01, hazard


ratio = 2.46) (Fig. 10b), and MBZ + SO-treated HCC mice (log-rank test P < 0.0001, hazard ratio = 7.45) (Fig. 10c), indicating that the drug-treated HCC mice exhibited higher survival


curves and survival % than the DEN-treated model mice. In addition, the MBZ + SO group demonstrated the highest survival probability among the treatment groups, as illustrated in Fig. 10f


(MBZ + SO vs. SO: log-rank test P = 0.04, hazard ratio = 2.91) and Fig. 10e (MBZ + SO vs. MBZ: log-rank test P = 0.01, hazard ratio = 3.62).” now reads: “The Kaplan–Meier survival curves


depicted in Fig. 10 reveal that DEN-treated model mice had higher mortality rates than MBZ-treated HCC mice (log-rank test P-adj = 0.04, hazard ratio = 2.03) (Fig. 10a), SO-treated HCC mice


(log-rank test P-adj = 0.03, hazard ratio = 2.46) (Fig. 10b), and MBZ + SO-treated HCC mice (log-rank test P-adj = 0.0005, hazard ratio = 7.45) (Fig. 10c), indicating that the drug-treated


HCC mice exhibited higher survival curves and survival % than the DEN-treated model mice. In addition, the MBZ + SO group demonstrated the highest survival probability among the treatment


groups, as illustrated in Fig. 10d (MBZ + SO vs. SO: log-rank test P-adj = 0.04, hazard ratio = 2.91) and Fig. 10e (MBZ + SO vs. MBZ: log-rank test P-adj = 0.03, hazard ratio = 3.62).”


Additionally, Figure 10 was revised to include adjusted P-values. The original Article has been corrected. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pharmaceutical


Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia Nancy S. Younis * Department of Pharmacology, Zagazig University, Zagazig, Egypt Nancy S.


Younis * Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt Amal M. H. Ghanim * Department of Pharmacology, Faculty of Pharmacy,


Delta University for Science and Technology, Gamasa, Egypt Sameh Saber Authors * Nancy S. Younis View author publications You can also search for this author inPubMed Google Scholar * Amal


M. H. Ghanim View author publications You can also search for this author inPubMed Google Scholar * Sameh Saber View author publications You can also search for this author inPubMed Google


Scholar CORRESPONDING AUTHOR Correspondence to Nancy S. Younis. RIGHTS AND PERMISSIONS OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0 International License,


which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link


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unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory


regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit


http://creativecommons.org/licenses/by/4.0/. Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Younis, N.S., Ghanim, A.M.H. & Saber, S. Author Correction: Mebendazole


augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma. _Sci Rep_ 12, 13607 (2022).


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