ABSTRACT Simplified first-trimester abortion protocols are well established. However, data on the use of medical or surgical abortion protocols across Switzerland is lacking. We report

protocol characteristics in abortion care for two different facility types, hospital vs private practices (office-based) in Switzerland. Furthermore, we investigate an association between

protocol characteristics and the likelihood of following through with the abortion at the same facility. We also report abortion outcomes of an office-based cohort where doctors use

simplified abortion protocols. This study consists of two parts. (i) Between April and July, 2019, we collected data regarding medical and surgical abortion protocols of institutions

office-based facilities from January, 2008, to December, 2018, using simplified abortion protocols in accordance with the Worlds Health Organisation (WHO) guidelines. (i) We included a total

of 39 institutions. Hospitals showed more protocol-based barriers to abortion access compared with office-based facilities. The odds of undergoing an abortion after the first appointment

were increased using protocols with minimal barriers. Overall, office-based facilities applied higher gestational age limits, required fewer appointments, and administered mifepristone more

often after the first visit than did hospitals. (ii) We included a total of 5274 patients with an incidence of complications requiring surgery of 2.5% in line with rates reported in

published literature. Only a few hospitals provide abortion care with easy access to medical and surgical abortion, whereas most office-based facilities do. Access to abortion services is

generally crucial, and should be provided in a single visit whenever clinically permissible. SIMILAR CONTENT BEING VIEWED BY OTHERS INCIDENCE OF MATERNAL NEAR-MISS IN KENYA IN 2018: FINDINGS

FROM A NATIONALLY REPRESENTATIVE CROSS-SECTIONAL STUDY IN 54 REFERRAL HOSPITALS Article Open access 16 September 2020 TREND, PREVALENCE, AND ASSOCIATED FACTORS OF UTERINE RUPTURE AT NEKEMTE

SPECIALIZED HOSPITAL, OROMIA REGIONAL STATE, WESTERN ETHIOPIA Article Open access 28 October 2024 IMMEDIATE AND DELAYED PLACEMENT OF THE INTRAUTERINE DEVICE AFTER ABORTION: A SYSTEMATIC

REVIEW AND META-ANALYSIS Article Open access 18 May 2024 INTRODUCTION First-trimester abortions can be performed safely either medically or surgically1. Since 2002, it has been a legal

requirement in Switzerland for first-trimester abortions to be provided to women on demand within the first 12 weeks of pregnancy2. Cantonal authorities approve public hospitals as well as

specialist general practitioners (GPs) and gynecologists within office-based settings to provide abortion care. Since statutory approval in 2002, the number of abortions remains stable at

one of the lowest levels in Europe. Around 11,000 first-trimester abortions are carried out every year, with 6.4 per 1000 individuals aged between 15 and 49 years3. At present, most

first-trimester abortions in Switzerland are medical, accounting for 74%, whereas 26% are conducted by suction evacuation3. Despite liberal abortion laws, Swiss guidelines5 indicate that

access to service and patient privacy may be compromised for several reasons. One argument for this is that mifepristone is not approved beyond 49 days after last menstrual period (LMP)4,

which is endorsed by the Swiss guidelines of Gynecology and Obstetrics (SGGG)5. Whilst the guideline considers an off-label use for later gestational ages, the responsibility lies with the

patient and the service provider5. Another reason is that cantons impose compulsory counselling on patients seeking abortion, despite the fact that this recommendation is not mandatory

according to Swiss law2. Moreover, home use of medical abortion medication is not common, and patients are obliged to attend another appointment in order to receive the medication.

Additionally, post-abortion care following medical abortion usually requires another clinical visit comprising an ultrasound to exclude an ongoing pregnancy. Taken together, these guidelines

oblige patients to attend three to four face-to-face appointments throughout the process, which delays abortion care and imposes barriers. International guidelines generally endorse

simplification of abortion care, including one-visit protocols, as this has been proven to be safe1,6,7,8,9,10,11. Based on clinical evidence12,13,14, these recommendations include medical

abortion up to 70 days after LMP and the removal of unnecessary barriers to abortion access, such as compulsory counselling1,9. These guidelines also support home use of medical abortion

medication and post-abortion care assessment via tele-medicine in conjunction with low-sensitivity urine pregnancy tests (LSUPC)15,16,17,18,19. However, data on the varied use of medical or

surgical abortion protocols across Switzerland by facility type is lacking. Our study intends to identify potential protocol-based barriers to abortion services with a focus on two different

health-care providers: hospitals versus office-based settings. Furthermore, we investigate a comprehensive one-decade dataset obtained from six GPs in Zurich with a focus on complications

requiring surgery. Their abortion protocols are straightforward and in line with the WHO guidelines. They thus support simplified access to abortion care. METHODS The study followed the

STROBE [Strengthening the Report of observational Studies in Epidemiology] guidelines for reporting observational studies, and consists of two parts20. PART 1 NATIONWIDE SURVEY STUDY DESIGN

AND SETTINGS We distributed a nationwide questionnaire among hospitals and private practices covering details of medical and surgical abortion protocols and numbers between April and July,

2019. In March 2019, we developed a questionnaire comprising nineteen multiple-choice questions pertaining to medical and surgical abortion protocols (Supplementary Information, SI Table

S1). This specific set of questions included answer options which are in line with the Swiss guidelines5, and answers which adhere to international guidelines, such as the WHO guidelines1.

This approach allowed us to identify different practices within the abortion process. Additionally, we asked for the annual number of patients seeking abortion at each institution, as well

as the annual number of abortions carried out between 2014 and 2018. As a result, we were able to identify a discrepancy between these numbers. Each questionnaire was translated into the

main Swiss languages (German, French, Italian) by a native speaker with a medical background. FACILITY RECRUITMENT AND ELIGIBILITY We identified two different types of service providers

offering abortion care in Switzerland. We grouped these institutions into hospitals and private practices (office-based setting). Therefore, we identified all Swiss teaching hospitals (which

are listed by the Swiss Institute for Medical Education register (SIWF)21) as well as authorised office-based GPs (which are listed by APAC-Suisse register) which specifically offer

abortion care22. Between April and May 2019, we contacted the directors of these institutions by post and asked them to complete the questionnaire. If a questionnaire was missing or

incomplete, we recontacted the facility for further enquiry via email after 4 weeks, and again after six weeks, if necessary. The institutions were required to confirm that the questions had

been answered by a fully qualified member of staff regularly involved in abortion services. In order to be eligible, the institution was required to offer both medical and surgical

abortion, and all the answers on the questionnaire concerning the abortion protocol for both procedures were required to be complete. DEFINITION OF PROTOCOL CHARACTERISTICS WHICH COMPLICATE

ACCESS TO ABORTION CARE Based on discrepancies between the Swiss and the WHO guidelines1 regarding abortion care, we defined protocol characteristics which may constitute barriers to

accessing the service. These factors are listed in Table 1. OUTCOMES The primary outcome was the proportion of patients who followed through with the abortion at the same facility,

calculated as the number of abortions carried out relative to the number of patients seeking abortion, and in each of the years 2014–2018. STATISTICAL ANALYSIS Statistical analyses were

performed in R version 4.0.4 (2021-02-15). Descriptive statistics of each facility’s characteristics and its abortion protocols were tabulated by facility type. Frequency and percentage were

reported for categorical variables, and mean and standard deviation for continuous variables. We defined explanatory variables considered as protocol characteristics complicating access to

abortion services (Table 1). In order to assess the association between abortion protocol characteristics and the proportion of patients who continued with their first-contact-provider, we

used binomial generalised estimating equations (GEE) with facility as a cluster term due to repeated measurements per facility (2014–2018). These measurements represent the number of

patients seeking abortion, and the number of abortions carried out per year and institution. We then fitted one GEE for each explanatory variable (single-variable model), and a multivariable

GEE with all explanatory variables (full model). Odds ratios with 95% confidence intervals (CI) and corresponding p-values are reported. PART 2 PATIENT COHORT FROM SIX GPS STUDY DESIGN AND

PATIENT POPULATION This cohort study was a retrospective analysis of a prospectively maintained and de-identified database from six office-based abortion care providers in Zurich,

Switzerland. Ethical approval was obtained (BASEC-No. Req-2018-01031). We included patients with first-trimester pregnancies treated by means of medical or surgical abortion with a follow-up

of at least 6 weeks between January 2008 and December 2018. Their abortion protocols are in line with the WHO guidelines1 and are shown in supplementary information (SI) Table S2. Follow-up

after medical abortion entailed a low-sensitivity urine pregnancy test combined with a telephone call assessing patient’s symptoms and history, whereas suction evacuation follow-up included

a phone call 6 weeks after surgery. OUTCOMES The primary outcome was the incidence of complications requiring surgery after a medical or surgical abortion, defined as suction evacuation due

to incomplete abortion, ongoing pregnancy, infection, or major haemorrhage. STATISTICAL ANALYSIS Descriptive statistics of the facility’s characteristics and their abortion protocols were

tabulated. Frequency and percentage were reported for categorical variables, and mean and standard deviation for continuous variables. ETHICAL APPROVAL This study has been approved by the

Ethical committee of the Canton of Zurich, Switzerland (BASEC-No. Req-2018-01031). We received an anonymised database from a cohort of six GPs comprising patient data which was prospectively

collected and de-identified. We performed all analyses in accordance with the relevant guidelines and regulations. CONSENT FOR PUBLICATION Informed consent was waived by the ethics

committee (Ethical committee of the Canton of Zurich, Switzerland, BASEC-No. Req-2018-01031). REPORTING GUIDELINES The authors have completed the STROBE reporting checklist. ETHICAL

STATEMENT The authors are accountable for all aspects of the work, ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and

resolved. The second part of the study contained anonymized patient data and was conducted in accordance with a clarification of responsibility, approved by the Ethics Committees of Zurich

(BASEC-Nr. Req-2018-01031). RESULTS PART 1 NATIONWIDE SURVEY Searching the SIWF registry for Swiss teaching hospitals and the APAC-Suisse registry for office-based institutions (GPs)

specifically offering abortion care resulted in a total of 66 hospitals and 21 office-based institutions. After two reminders, 31 hospitals and 15 GPs returned the questionnaire,

corresponding to a response rate of 53%. We excluded four hospitals and one GP as they did not have a written protocol regarding abortion care. Furthermore, two hospitals were ineligible as

they did not offer abortion services at all. We thus included a total of 39 institutions, 25 hospitals and 14 office-based facilities for further analysis. The study flow chart is depicted

in Fig. 1. The institutions’ reported annual number of clinical visits from patients seeking medical as well as surgical abortion, and the annual number of abortions carried out between 2014

and 2018 are shown in the Supplementary Information (SI) Table S3. Additionally, the number of abortions performed in Switzerland compared with the number and proportion of abortions

performed in the 39 institutions is presented in the SI Table S4. The abortion protocol characteristics according to facility type are shown in Table 2. Office-based settings were

characterised by fewer clinical visits necessitating the involvement of fewer staff members, no mandatory reflection period, a higher proportion applying a gestational age limit of more than

63 days, the availability of abortion medication for home use in the case of medical abortion, and a higher proportion of telemedicine follow-up in conjunction with a semiquantitative urine

human chorionic gonadotropin test. The vast majority of hospitals and office-based settings confirmed that the cost of a medical abortion is fully reimbursed (cost efficient) at 80% and

85%, respectively. For surgical abortion, however, hospitals were far less likely to confirm full reimbursement of costs compared with office-based institutions, at 40% and 78%,

respectively. ASSOCIATION BETWEEN PROTOCOL COMPLEXITY AND THE PROPORTION OF PATIENTS UNDERGOING AN ABORTION (FIGS. 2, 3) Protocol characteristics complicating access to abortion services as

defined in Table 1 were associated with decreased odds of following through with the abortion at the same facility after the first appointment, whereas less complex protocols led to

increased odds of undergoing an abortion. Figure 2 shows the unadjusted odds ratios (ORs) from the single-variable model, whereas Fig. 3 shows the adjusted ORs from the full model. PART 2

PATIENT COHORT FROM SIX GPS STUDY DESIGN AND PATIENT POPULATION Between January 2008, and December, 2018, 5495 women sought an office-based first-trimester abortion. Patient characteristics

are shown in Table 3. The proportion of medical abortions and suction evacuations changed over time: in 2009, 65% were medical abortions, and 35% were surgical. In 2018, 75% were medical and

25% surgical abortions. FOLLOW-UP AND COMPLICATION RATES OF PATIENTS FROM THE SIX GPS The complication rates are shown in Table 4. A total of 5,274 patients were included in the calculation

of complication incidence. The mean follow-up was three months (from 6 weeks to 6 months). Two hundred and twenty-one patients (4.02%) from a total of 5495 were lost to follow-up. The

incidence of complications requiring surgery was at a low level of 2.5%. DISCUSSION PART 1 NATIONWIDE SURVEY Taking into account discrepancies between straightforward international abortion

guidelines1,9,11 and the Swiss guidance4,5, we compared nationwide first-trimester abortion protocols regarding medical and surgical abortion in hospitals as opposed to office-based

settings, as the latter were hypothesised to be more straightforward and easier to access. Furthermore, we investigated associations between protocol characteristics and the proportion of

patients who followed through with the abortion at the same facility. Our results indicate that less complex protocol characteristics, which are more common among office-based facilities,

are associated with higher odds of following through with the abortion at the same facility. By contrast, more complex abortion protocols, which are more common in hospitals, appear to

decrease the odds that a patient will follow through with the abortion at the same facility. Office-based settings were characterised by fewer clinical visits requiring the involvement fewer

staff members, no mandatory reflection period, a higher proportion applying a gestational age limit of more than 63 days, the availability of medical abortion medication for home use, and a

higher proportion of telemedicine follow-up in conjunction with a semiquantitative urine human chorionic gonadotropin test. Repeated assessments and counselling may cause delays in

accessing abortion services and are not recommended by several guidelines, including those of the WHO1,6,7,8,9,11. Furthermore, reduced waiting times and fewer clinical visits decrease

distress and improve patient experience7,8,19,23,24. However, an argument in favour of repeated assessments may be that more time is needed to determine the patient’s needs in terms of

somatic or psychological comorbidities. Nevertheless, most women have already decided on abortion before their first contact with the care provider, and they are aware of contraceptive

methods and how to use them. Hence, the imposition of a requirement for further counselling or a mandatory reflection period seems unethical and results in unnecessary barriers restricting

access to this service. Our results indicate that the gestational age limit appears to be an important protocol characteristic affecting the number of those who follow through with a medical

abortion at the same facility when the service is offered up to a limit of 63 days or beyond. Hospitals were found to be more restrictive regarding the gestational age limit compared with

GPs. Consequently, patients were not permitted to choose between a medical or surgical abortion and were obliged undergo a suction evacuation. This fact may have led to a decreased

proportion of patients following through with an abortion at the same facility. Multiple studies have shown the safety and effectiveness of medical abortions up to 70 days of pregnancy with

a regimen of 200 mg mifepristone followed by a single dose of misoprostol1,12,13,14,25,26,27. A systematic review conducted by Abbas et al. showed an overall success rate of 92.3% and an

overall ongoing pregnancy rate of 3.1% between 64 and 70 days. No statistically significant difference in success rate could be demonstrated compared with a gestational age up to 63 days

after LMP (93.9%)14. Regarding home use of medical abortion medication, in the single-variable model (Fig. 2), the odds of following through with an abortion at the same facility were

increased when offered (OR 5.55, 95% CI 3.15 to 9.79). In contrast, the full model (Fig. 3) suggests the opposite (OR 0.20, 95% CI 0.07 to 0.55). The reason for this discrepancy (and others)

between single-variable models (which ignore all other explanatory variables) and the full model is that ORs estimated by the full model are adjusted for all other explanatory variables in

the model. The full model estimates the OR for home use of medical abortion medication by patients in the same category for all other explanatory variables. Home use of medical abortion

medication was permitted more often by institutions which required fewer clinical visits, and by facilities which did not impose a mandatory reflection period or which allowed for the

administering of mifepristone at the first appointment. Thus, these variables partly explain the same variation, and the adjusted OR estimate for home use of medical abortion medication

(independently of the other variables) is reversed. However, home use is safe and effective, showing that health professionals are no longer obliged to directly dispense the medication to

patients12,24,28,29,30. Clinicians can prescribe mifepristone, misoprostol, and pain medications for home use, which may enhance patient experience and increase satisfaction and privacy, the

latter of which is pivotal in abortion care. Another argument in favour of home use of abortion medication is the similarity of the situation compared with that of patients suffering from a

first-trimester miscarriage, who are less prepared and who may even endure the process without relying on painkillers, despite experiencing comparable somatic and psychological pain. In

this study, only 8% of hospitals and 29% of GPs gave women the opportunity for post-abortion follow-up through self-assessment in conjunction with a semiquantitative urine human chorionic

gonadotropin test instead of a routine clinical visit. In Switzerland, the distance between a patient's place of residence and an abortion provider is generally short, and insurance

companies reimburse the costs for an ultrasound assessment. However, guidelines no longer endorse in-person visits with routine clinical follow-up, since remote and self-assessment along

with a telephone call are viable alternatives to in-person follow-up7,8,28. Oppegaard et al. demonstrated that self-assessment in conjunction with a semiquantitative urine human chorionic

gonadotropin test and standardised assessment of women’s symptoms were not inferior to standard clinical follow-up in terms of complication rates15,31. Self-assessment and telemedicine are

especially valuable in resource-poor settings and sparsely populated regions, and they also proved their worth during the COVID-19 pandemic15,32. Experience has shown that many patients do

not return to in-person follow-up after medical abortions in Switzerland, despite the fact that the costs are reimbursed. Hence, self-assessment could be an appropriate alternative, which is

currently still underrepresented15. These arguments are supported by the fact that ongoing pregnancies are low at around 0.4–3% in early medical abortions using a standard regimen with

mifepristone and misoprostol10,16,33,34,35. More importantly, patients undergoing ultrasound assessment frequently receive unnecessary interventions following a medical abortion, such as

suction evacuation for misinterpreted residual abortion material caused by inexperienced providers15. The failure rate of surgical abortion is approximately the same as that of medical

abortion, and an in-person follow-up visit is not required for the latter procedure9. Cost-efficiency of surgical abortion has only been confirmed by 40% of hospitals compared to 77.8% among

GPs, which might be directly related to more complicated protocols. However, amid growing concerns regarding cost reimbursement, hospitals should be encouraged to adjust their abortion

protocols, as safety and effectiveness are seemingly uncompromised10. The first part of the present study has several limitations. Firstly, the variables were self-reported by a

representative of each institution based on questionnaires. Secondly, the response rate was low (53%), accounting for 34–41% of all abortions in Switzerland within the years 2014–2018. The

French speaking part was the least represented in this study. Thirdly, following through with the abortion at the same facility is not necessarily a proxy for patient acceptability as we did

not include any direct patient perspective in this study. Fourthly, we did not statistically account for repeat abortions within the same patient in the analysis plan as this appeared to be

a rare event within a period of 5 years. PART 2 PATIENT COHORT FROM SIX GPS Simultaneously, we aimed to analyse a considerable dataset, obtained from six specialist GPs in Zurich, in terms

of complication rates requiring surgery. GPs are acknowledged for their simplified protocols. From 2008 to 2018, 5495 first-trimester abortions were performed. Of these (a total of 5495),

75% and 25% were performed by medical or surgical means, respectively. Despite simplified protocols, the overall complication rate requiring suction evacuation was at a low level of 2.5%.

This rate is comparable to those of other studies investigating the same setting10,14,15,16,19,36. Major haemorrhage, ongoing pregnancies and the patient’s decision to refuse another dose of

misoprostol were included in this 2.5% suction evacuation or reaspiration rate, respectively. The number lost to follow-up was low at 4.02%. There were similar complication rates compared

to those reported in the literature14. In a retrospective cohort study conducted by Robertson et al. of more than 50,000 abortions, abortion-related morbidities and adverse events were

compared by facility type (hospitals vs office-based settings). The overall proportion of patients with abortion-related morbidity or adverse events was 3.3%, which does not indicate a

significant difference between the two facility types37. The limitations of the second part of this study are as follows. Firstly, despite a complete dataset from six specialised GPs over a

decade, it only represents a small cohort and is not nationwide. Secondly, the complication rates requiring surgery were not further specified. Retained tissue, abortion-related infection,

haemorrhage, ongoing pregnancies, and missed ectopic pregnancies were not further specified. Therefore, the minor and major adverse events could not be differentiated. CONCLUSION The study

highlights the fact that few hospitals provide abortion care with easy access to medical and surgical abortion whereas most office-based facilities do. Unnecessary barriers, including

repetitive counselling and undesired in-person visits, should be avoided because they are no longer recommended by international guidelines for patients seeking abortion care. Abortion

services should be provided in a single visit whenever clinically permissible. DATA AVAILABILITY All data are available upon request to the corresponding author. REFERENCES * WHO. _Safe

Abortion: Technical and Policy Guidance for Health Systems_, 2nd edn. https://apps.who.int/iris/bitstream/handle/10665/70914/9789241548434_eng.pdf (2012). * _Schweizerisches Strafgesetzbuch

StGB, Swiss Criminal Code_.

https://fedlex.data.admin.ch/filestore/fedlex.data.admin.ch/eli/cc/54/757_781_799/20200701/de/pdf-a/fedlex-data-admin-ch-eli-cc-54-757_781_799-20200701-de-pdf-a.pdf (2020) (15 August 2021).

* Abortion. _Federal Office of Statistics_. https://www.bfs.admin.ch/bfs/de/home/statistiken/gesundheit/gesundheitszustand/reproduktive/schwangerschaftsabbrueche.html. * Mifepristonum.

_Swissmedic-Agency for Regulation of Prescription Drugs_. https://compendium.ch/product/1005481-mifegyne-tabl-200-mg/mpro (1999). * Renteria, S.-C. _et al._ _Expertenbrief No 65

Medikamentöer Schwangerschaftsabbruch im ersten Trimester_. https://www.sggg.ch/fileadmin/user_upload/65_Medikamentoeser_Schwangerschaftsabbruch_im_ersten_Trimester.pdf (2020) (25 May 2022).

* ACOG. _Practice Bulletin No. 143: Medical Management of First-Trimester Abortion_.

https://www.acog.org/-/media/project/acog/acogorg/clinical/files/practice-bulletin/articles/2014/03/medical-management-of-first-trimester-abortion.pdf (2014). * (UK), N. G. A. _Abortion

care. NICE Guideline No. 140_ (2019). * Federation, N. A. _Clinical Policy Guidelines for Abortion Care_ (2020). * Costescu, D. _et al._ Medical abortion. _J. Obstet. Gynaecol. Can._ 38(4),

366–389 (2016). Article  PubMed  Google Scholar  * Schummers, L. _et al._ Abortion safety and use with normally prescribed mifepristone in Canada. _N. Engl. J. Med._ 386(1), 57–67 (2022).

Article  CAS  PubMed  Google Scholar  * Societyfp. _Society of Family Planning—Practice Guidelines_. https://www.societyfp.org/clinical-guidance/. (2023) (Accessed 21 February 2023). *

Winikoff, B. _et al._ Extending outpatient medical abortion services through 70 days of gestational age. _Obstet. Gynecol._ 120(5), 1070–1076 (2012). Article  PubMed  Google Scholar  *

Boersma, A. A., Meyboom-de Jong, B. & Kleiverda, G. Mifepristone followed by home administration of buccal misoprostol for medical abortion up to 70 days of amenorrhoea in a general

practice in Curacao. _Eur. J. Contracept. Reprod. Health Care_ 16(2), 61–66 (2011). Article  CAS  PubMed  Google Scholar  * Abbas, D., Chong, E. & Raymond, E. G. Outpatient medical

abortion is safe and effective through 70 days gestation. _Contraception_ 92(3), 197–199 (2015). Article  PubMed  Google Scholar  * Oppegaard, K. S. _et al._ Clinical follow-up compared with

self-assessment of outcome after medical abortion: A multicentre, non-inferiority, randomised, controlled trial. _Lancet_ 385(9969), 698–704 (2015). Article  PubMed  Google Scholar  *

Grossman, D. & Grindlay, K. Alternatives to ultrasound for follow-up after medication abortion: A systematic review. _Contraception_ 83(6), 504–510 (2011). Article  PubMed  Google

Scholar  * Endler, M. _et al._ Safety and acceptability of medical abortion through telemedicine after 9 weeks of gestation: A population-based cohort study. _BJOG_ 126(5), 609–618 (2019).

Article  CAS  PubMed  Google Scholar  * Seidenberg, A. & Fiala, C. One Stop MToP. _Swiss Medical Forum_ 15(34), 745–748 (2015). Google Scholar  * Baiju, N. _et al._ Effectiveness, safety

and acceptability of self-assessment of the outcome of first-trimester medical abortion: A systematic review and meta-analysis. _BJOG_ 126(13), 1536–1544 (2019). Article  CAS  PubMed 

Google Scholar  * Vandenbroucke, J. P. _et al._ Strengthening the reporting of observational studies in epidemiology (STROBE): Explanation and elaboration. _Epidemiology_ 18(6), 805–835

(2007). Article  PubMed  Google Scholar  * SIWF. _Swiss Institute for Medical Education_. https://www.siwf-register.ch/ (2021). * APAC. _APAC Swiss Study Group for Abortion and

Contraception_. https://schwangerschaftsabbruch.org/. * Fiala, C. _et al._ Acceptability of home-use of misoprostol in medical abortion. _Contraception_ 70(5), 387–392 (2004). Article  CAS 

PubMed  Google Scholar  * Tan, Y. L. _et al._ Acceptability and feasibility of outpatient medical abortion with mifepristone and misoprostol up to 70 days gestation in Singapore. _Eur. J.

Obstet. Gynecol. Reprod. Biol._ 229, 144–147 (2018). Article  CAS  PubMed  Google Scholar  * Chen, M. J. & Creinin, M. D. Mifepristone with buccal misoprostol for medical abortion: A

systematic review. _Obstet. Gynecol._ 126(1), 12–21 (2015). Article  CAS  PubMed  Google Scholar  * Raymond, E. G. _et al._ First-trimester medical abortion with mifepristone 200 mg and

misoprostol: A systematic review. _Contraception_ 87(1), 26–37 (2013). Article  CAS  PubMed  Google Scholar  * Bracken, H. _et al._ A two-pill sublingual misoprostol outpatient regimen

following mifepristone for medical abortion through 70 days’ LMP: A prospective comparative open-label trial. _Contraception_ 89(3), 181–186 (2014). Article  CAS  PubMed  Google Scholar  *

American College of Obstetricians and Gynecologists. Medication abortion up to 70 days of gestation: ACOG Practice Bulletin, Number 225. _Obstet. Gynecol._ 136(4), e31–e47 (2020). Article 

Google Scholar  * Conkling, K. _et al._ A prospective open-label study of home use of mifepristone for medical abortion in Nepal. _Int. J. Gynaecol. Obstet._ 128(3), 220–223 (2015). Article

  PubMed  Google Scholar  * Raghavan, S. _et al._ Efficacy and acceptability of early mifepristone-misoprostol medical abortion in Ukraine: Results of two clinical trials. _Eur. J.

Contracept. Reprod. Health Care_ 18(2), 112–119 (2013). Article  CAS  PubMed  Google Scholar  * Clark, W. _et al._ Alternatives to a routine follow-up visit for early medical abortion.

_Obstet. Gynecol._ 115(2 Pt 1), 264–272 (2010). Article  PubMed  Google Scholar  * RCOG. _Coronavirus (COVID-19) Infection and Abortion Care. Version 3.1_.

https://www.rcog.org.uk/globalassets/documents/guidelines/2020-07-31-coronavirus-covid-19-infection-and-abortion-care.pdf (2020). * Spitz, I. M. _et al._ Early pregnancy termination with

mifepristone and misoprostol in the United States. _N. Engl. J. Med._ 338(18), 1241–1247 (1998). Article  CAS  PubMed  Google Scholar  * Fjerstad, M. _et al._ Effectiveness of medical

abortion with mifepristone and buccal misoprostol through 59 gestational days. _Contraception_ 80(3), 282–286 (2009). Article  CAS  PubMed  PubMed Central  Google Scholar  * Kahn, J. G. _et

al._ The efficacy of medical abortion: A meta-analysis. _Contraception_ 61(1), 29–40 (2000). Article  CAS  PubMed  Google Scholar  * Perriera, L. K. _et al._ Feasibility of telephone

follow-up after medical abortion. _Contraception_ 81(2), 143–149 (2010). Article  PubMed  Google Scholar  * Roberts, S. C. M. _et al._ Association of facility type with procedural-related

morbidities and adverse events among patients undergoing induced abortions. _JAMA_ 319(24), 2497–2506 (2018). Article  PubMed  PubMed Central  Google Scholar  Download references

ACKNOWLEDGEMENTS The authors would like to thank André Seidenberg, MD, Bruno Maggi, MD, Daniel Oertle, MD, Heinrich Diggelmann, MD, Benjamin Stutz, MD, and Choon-Kang Walther, MD, for their

valuable contributions in providing anonymised complete datasets about first-trimester abortion in their office-based settings. Furthermore, the authors thank all participants from hospitals

and office-based services for their valuable replies to the questionnaires, which made this study possible. We would also like to thank Dr Radhika Merh and Marguerite Dallas for English

language editing. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Gynaecology, Spital Limmattal, Zurich, Switzerland Samuel Martin Eckstein * Department of Biostatistics at

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland Stefanie von Felten * Department of Gyaecology, Cantonal Hospital Winterthur, Winterthur,

Switzerland Laura Perotto * Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland Romana Brun * Department of Gynaecology, University Hospital Zurich, Frauenklinikstrasse

10, 8091, Zurich, Switzerland Denise Vorburger Authors * Samuel Martin Eckstein View author publications You can also search for this author inPubMed Google Scholar * Stefanie von Felten

View author publications You can also search for this author inPubMed Google Scholar * Laura Perotto View author publications You can also search for this author inPubMed Google Scholar *

Romana Brun View author publications You can also search for this author inPubMed Google Scholar * Denise Vorburger View author publications You can also search for this author inPubMed 

Google Scholar CONTRIBUTIONS S.M.E.: Initiated the conceptual study design, retrieved clinical data, conducted the complete data analysis including statistics and drafted the paper. S.V.F.:

Conducted and supervised the complete data analysis including statistics and drafted the paper. L.P./R.B.: Critically read the manuscript. D.V.: Initiated the conceptual study design,

supervised data retrieval, critically analysed the data and drafted and revised the paper. CORRESPONDING AUTHOR Correspondence to Denise Vorburger. ETHICS DECLARATIONS COMPETING INTERESTS

The authors declare no competing interests. ADDITIONAL INFORMATION PUBLISHER'S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and

institutional affiliations. SUPPLEMENTARY INFORMATION SUPPLEMENTARY TABLES. RIGHTS AND PERMISSIONS OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0 International

License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source,

provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative

Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not

permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit

http://creativecommons.org/licenses/by/4.0/. Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Eckstein, S.M., von Felten, S., Perotto, L. _et al._ First trimester abortion

protocols by facility type in Switzerland and potential barriers to accessing the service. _Sci Rep_ 13, 6814 (2023). https://doi.org/10.1038/s41598-023-34101-2 Download citation * Received:

18 December 2022 * Accepted: 24 April 2023 * Published: 26 April 2023 * DOI: https://doi.org/10.1038/s41598-023-34101-2 SHARE THIS ARTICLE Anyone you share the following link with will be

able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing

initiative