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Access through your institution Buy or subscribe Standardized mouse inbred strains have been central to biomedical research for decades, ensuring experimental reproducibility across
laboratories and experiments. However, the lack of genetic diversity within and between inbred mouse strain is an important limitation. A study in _Plos Genetics_ reports the development of
a new set of 11 inbred strains derived from wild-caught _Mus musculus domesticus_, sampled from five environmentally distinct locations across North and South America. These ‘Nachman
strains’, which harbor millions of genetic variants absent from current laboratory mouse models, showed extensive phenotypic diversity when tested for several metabolic, neurobehavioral,
physiological, morphological and biochemical traits. This new wild-derived inbred strain panel complements existing diverse mouse panels, such as the BXD, the collaborative cross or the
hybrid mouse diversity panel, and contributes to expand the range of trait variation observed in laboratory mice. ORIGINAL REFERENCE: Dumont, B. L. et al_. PLoS Genet_. 20, e1011228 (2024)
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subscriptions * Read our FAQs * Contact customer support AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Lab Animal http://www.nature.com/laban/ Alexandra Le Bras Authors * Alexandra Le Bras
View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Alexandra Le Bras. RIGHTS AND PERMISSIONS Reprints and permissions
ABOUT THIS ARTICLE CITE THIS ARTICLE Le Bras, A. Wild mice for research. _Lab Anim_ 53, 108 (2024). https://doi.org/10.1038/s41684-024-01365-8 Download citation * Published: 03 May 2024 *
Issue Date: May 2024 * DOI: https://doi.org/10.1038/s41684-024-01365-8 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link
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