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Shedding light on the mechanisms that underlie a durable response to immunotherapy, a recent study evaluating long-term survivors of melanoma treated with immunotherapy finds that
tumor-associated T cell clonotypes are sustained over years and persist as expanded, cytokine IFN-γ–expressing resident memory T cells in the skin, with effector memory counterparts in the
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AUTHORS AND AFFILIATIONS * La Jolla Institute for Allergy & Immunology, La Jolla, CA, USA Anusha-Preethi Ganesan & Christian H. H. Ottensmeier * Division of Pediatric Hematology
Oncology, Rady Children’s Hospital, University of California San Diego, San Diego, CA, USA Anusha-Preethi Ganesan * University of Liverpool, Institute of Systems, Molecular and Integrative
Biology, Head and Neck Center, Liverpool, UK Christian H. H. Ottensmeier * The Clatterbridge Cancer Center NHS Foundation Trust, Liverpool, UK Christian H. H. Ottensmeier Authors *
Anusha-Preethi Ganesan View author publications You can also search for this author inPubMed Google Scholar * Christian H. H. Ottensmeier View author publications You can also search for
this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Christian H. H. Ottensmeier. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests.
RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ganesan, AP., Ottensmeier, C.H.H. Melanoma-reactive T cells take up residence. _Nat Cancer_ 2, 253–255
(2021). https://doi.org/10.1038/s43018-021-00189-6 Download citation * Published: 24 March 2021 * Issue Date: March 2021 * DOI: https://doi.org/10.1038/s43018-021-00189-6 SHARE THIS ARTICLE
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