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Access through your institution Buy or subscribe “In 2013, we published our finding that HMM-HA is responsible for cancer resistance in the naked mole-rat. From that time on, we wanted to
test whether this mechanism could be transferred to other species, and whether HMM-HA is needed for longevity and not only for cancer resistance. It took us another 10 years to find the
answer … ”, says Vera Gorbunova, one of the corresponding authors of the study. The research team generated a mouse model into which they introduced an inducible copy of the naked mole-rat
_Has2_ gene. “Our laboratory has always been interested in identifying longevity mechanisms that were selected by evolution and then finding ways to potentially translate them to humans. In
this case, we moved a gene from a long-lived mammal to a short-lived mammal to see whether it conferred benefits”, explains Gorbunova. This is a preview of subscription content, access via
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institutional subscriptions * Read our FAQs * Contact customer support AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Aging https://www.nature.com/nataging/ Sebastien Thuault Authors *
Sebastien Thuault View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Sebastien Thuault. RIGHTS AND PERMISSIONS
Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Thuault, S. Exporting longevity adaptations. _Nat Aging_ 3, 1176 (2023). https://doi.org/10.1038/s43587-023-00507-w Download
citation * Published: 12 October 2023 * Issue Date: October 2023 * DOI: https://doi.org/10.1038/s43587-023-00507-w SHARE THIS ARTICLE Anyone you share the following link with will be able to
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