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Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based
immune checkpoint enables senescent cells to evade immune surveillance mediated by natural killer cells during aging, and that targeting GD3 is protective in age-related disease. Access
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taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Ovadya, Y. et
al. _Nat. Commun._ 9, 5435 (2018). Article CAS PubMed PubMed Central Google Scholar * Krizhanovsky, V. et al. _Cell_ 134, 657–667 (2008). Article CAS PubMed PubMed Central Google
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Central Google Scholar * Wang, T. W. et al. _Nature_ 611, 358–364 (2022). Article CAS PubMed Google Scholar Download references ACKNOWLEDGEMENTS V.K. was supported by grants from the
European Research Council (856487), from the Israel Science Foundation (1626/20), DFG - CRC 1506 “Aging at Interfaces”, Weizmann - Nella and Leon Benoziyo Center for Neurological Diseases,
Weizmann - Sagol Center for Research on the Aging Brain, Weizmann SABRA - Yeda-Sela - WRC Program, the Estate of Emile Mimran, and The Maurice and Vivienne Wohl Biology Endowment. AUTHOR
INFORMATION AUTHORS AND AFFILIATIONS * Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel Julia Majewska & Valery Krizhanovsky Authors * Julia Majewska
View author publications You can also search for this author inPubMed Google Scholar * Valery Krizhanovsky View author publications You can also search for this author inPubMed Google
Scholar CORRESPONDING AUTHOR Correspondence to Valery Krizhanovsky. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and
permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Majewska, J., Krizhanovsky, V. GD3 ganglioside checkpoints in immune surveillance of senescent cells. _Nat Aging_ 5, 182–183 (2025).
https://doi.org/10.1038/s43587-025-00803-7 Download citation * Published: 15 January 2025 * Issue Date: February 2025 * DOI: https://doi.org/10.1038/s43587-025-00803-7 SHARE THIS ARTICLE
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