Visualizing inflammatory monocytes and macrophages in the human heart

Visualizing inflammatory monocytes and macrophages in the human heart

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Inflammatory monocytes and macrophages in the heart express C-C chemokine receptor 2 (CCR2) on their cell surface and contribute to heart failure pathogenesis. This study established the


feasibility of imaging CCR2+ cells by positron emission tomography in patients with myocardial infarction. Access through your institution Buy or subscribe This is a preview of subscription


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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Bajpai, G. et al. The human heart contains distinct


macrophage subsets with divergent origins and functions. _Nat. Med._ 24, 1234–1235 (2018). THIS PAPER DEMONSTRATES THE RELEVANCE OF CCR2+ MONOCYTES AND MACROPHAGES IN THE HUMAN HEART.


Article  CAS  PubMed  PubMed Central  Google Scholar  * Wienecke, L. M. et al. Imaging targets to visualize the cardiac immune landscape in heart failure. _Circ. Cardiovasc. Imaging_ 16,


e014071 (2023). A REVIEW ARTICLE THAT SUMMARIZES IMMUNE CELLS AND BIOMARKERS FOR HEART IMAGING. Article  PubMed  Google Scholar  * Heo, G. S. et al. Molecular imaging visualizes recruitment


of inflammatory monocytes and macrophages to the injured heart. _Circ. Res._ 124, 881–890 (2019). THIS PAPER REPORTS THE FIRST CCR2 TARGETED PET IMAGING OF THE INJURED HEART. Article  CAS 


PubMed  PubMed Central  Google Scholar  * Brody, S. L. et al. Chemokine receptor 2-targeted molecular imaging in pulmonary fibrosis. A clinical trial. _Am. J. Respir. Crit. Care Med._ 203,


78–89 (2021). THIS PAPER REPORTS THE FIRST INVESTIGATION OF CCR2 IMAGING IN HUMANS. Article  CAS  PubMed  PubMed Central  Google Scholar  * Heo, G. S. et al. Nuclear methods for immune cell


imaging: bridging molecular imaging and individualized medicine. _Circ. Cardiovasc. Imaging_ 16, e014067 (2023). A REVIEW ARTICLE THAT SUMMARIZES NUCLEAR APPROACHES FOR IMMUNE CELL IMAGING.


Article  PubMed  Google Scholar  Download references ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and


institutional affiliations. THIS IS A SUMMARY OF: Lavine, K. J. et al. CCR2 imaging in human ST-segment elevation myocardial infarction. _Nat. Cardiovasc. Res_.


https://doi.org/10.1038/s44161-023-00335-6 (2023). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Visualizing inflammatory monocytes and macrophages in


the human heart. _Nat Cardiovasc Res_ 2, 869–870 (2023). https://doi.org/10.1038/s44161-023-00345-4 Download citation * Published: 26 September 2023 * Issue Date: October 2023 * DOI:


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