ABSTRACT Though Deflazacort and prednisone improve clinical endpoints in Duchenne muscular dystrophy (DMD) patients, Deflazacort produces fewer side effects. As mechanisms of improvement and

side effect differences remain unknown, we evaluated effects of corticosteroid administration on gene expression in blood of DMD patients. Whole blood was obtained from 14 children and

adolescents with DMD treated with corticosteroids (DMD-STEROID) and 20 DMD children and adolescents naïve to corticosteroids (DMD). The DMD-STEROID group was further subdivided into

Deflazacort and prednisone groups. Affymetrix U133 Plus 2.0 expression microarrays were used to evaluate mRNA expression. Expression of 524 probes changed with corticosteroids, including

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Google Scholar  Download references ACKNOWLEDGEMENTS We thank the nurses and study coordinators who helped with these studies at Cincinnati Children's Hospital Medical Center. We also

thank the Affymetrix cores for processing the samples. This study was supported by NIH/NINDS Grants (NS043252 and NS056302, FRS), support from Cincinnati Children's Hospital Medical

Center (BW), and support from the M.I.N.D. Institute at the University of California at Davis (FRS, LL, IL, WW, MA). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Neurology,

MIND Institute, University of California at Davis, Sacramento, CA, USA L Lit, F R Sharp, M Apperson, D Z Liu, W L Walker, I Liao, H Xu & B P Ander * Department of Pediatric Neurology,

Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA B Wong Authors * L Lit View author publications You can also search for this author

inPubMed Google Scholar * F R Sharp View author publications You can also search for this author inPubMed Google Scholar * M Apperson View author publications You can also search for this

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this author inPubMed Google Scholar * I Liao View author publications You can also search for this author inPubMed Google Scholar * H Xu View author publications You can also search for this

author inPubMed Google Scholar * B P Ander View author publications You can also search for this author inPubMed Google Scholar * B Wong View author publications You can also search for

this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to L Lit. ADDITIONAL INFORMATION Supplementary Information accompanies the paper on the The Pharmacogenomics Journal

website (http://www.nature.com/tpj) SUPPLEMENTARY INFORMATION SUPPLEMENTARY TABLE S-1 (XLS 320 KB) SUPPLEMENTARY FIGURE S-1 (JPG 73 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE Lit, L., Sharp, F., Apperson, M. _et al._ Corticosteroid effects on blood gene expression in Duchenne muscular dystrophy. _Pharmacogenomics J_ 9, 411–418

(2009). https://doi.org/10.1038/tpj.2009.22 Download citation * Received: 12 December 2008 * Revised: 03 April 2009 * Accepted: 14 April 2009 * Published: 02 June 2009 * Issue Date: December

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not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Duchenne muscular dystrophy * corticosteroid *

prednisone * microarray * gene expression