AGING OF THE HUMAN IMMUNE SYSTEM ACROSS THE WHOLE LIFESPAN Wang et al. profile the evolution of peripheral immune cell diversity, function and interactions at the single-cell transcriptional

and protein levels, across eight distinct stages from birth to old age. The artwork conceptualizes the human peripheral immune system as a vibrant and evolving garden, where the flowers

symbolize the dynamic changes in various immune cell populations and states with the passage of life. See Wang et al. Image: Lulu Zhang, August Fireflies Technology; concept by: Ronghong Li

and Jun Pu, Renji Hospital, Shanghai Jiao Tong University School of Medicine. Cover design: Vanitha Selvarajan