NEW PARP TARGETS FOR CANCER THERAPY The poly(ADP-ribose) polymerase (PARP) family comprises 17 enzymes, which generate poly(ADP-ribose) and/or mono(ADP-ribose) (MAR) that can modify target

protein function and can function as a signalling scaffold. These modifications may have various roles in cancer and, as discussed in this Opinion article, inhibitors of MARylation in

particular may warrant investigation as anticancer drugs. * Sejal Vyas * Paul Chang