GENETIC DETERMINANTS OF PLASMA LIPOPROTEINS In addition to environmental factors, genetic variation exerts a sizeable, complex influence on lipoprotein phenotypes. Rebecca Pollex and Robert

Hegele review recent progress on genomic variants and cholesterol metabolism, focusing on key, well-characterized genes that are determinants of plasma lipoproteins and have shown consistent

results over the years, and discuss their potential utility in clinical cardiology. * Rebecca L Pollex * Robert A Hegele