In this issue, read about immunostimulation from chemotherapeutic agents, cancer in older adults, ctDNA applications in colorectal cancer and artificial intelligence in radiotherapy. Image

of a primary human invasive ductal carcinoma tissue section stained for immune cells supplied by Ms Sayali Onkar, University of Pittsburgh School of Medicine, and Dr. Marion Joy, National

Surgical Adjuvant Breast and Bowel Project. Cover design: Simon Bradbrook.