Our November issue includes articles on Guillain–Barré syndrome, migraine, Charcot–Marie–Tooth disease, and early-life adversity and neurological disease. The cover depicts a membranous

cytoplasmic body, a neuronal lipid inclusion that is characteristic of the neurodegenerative lysosomal storage disorder Tay–Sachs disease. Supplied by Luciana E. Giono, Institute for

Physiology, Molecular Biology and Neurosciences, University of Buenos Aires, Argentina. Cover design: Philip Patenall.