One big fan of the _Big Bang Theory _got a special shout-out during last night’s episode, all thanks to Kaley Cuoco. The actress, 33, dedicated Thursday night’s antepenultimate episode to

Isaiah Zarate, a friend of Cuoco’s who has a rare, genetic skin disorder called epidermolysis bullosa. “Tonight’s NEW episode @bigbangtheory_cbs is in honor of my sensational friend Isaiah

@redguy29!” she wrote on Instagram, along with photos with Zarate on set. “He has sat in the front row of our audience for the entire run of season 12. He suffers from @ebmrf, yet when I

look into the crowd, he always has the biggest smile on his face.” Cuoco said that Zarate is her “inspiration.” “He has become quite a key player here at BBT and I couldn’t love him more,”

actually a group of rare skin diseases, according to the Mayo Clinic, that cause blisters all over the body. Even the smallest of injuries, like scratching or rubbing the skin, can lead to

the blisters. The only treatment is to care for the blisters until they heal. Cuoco is closely involved with the Epidermolysis Bullosa Medical Research Foundation, and helps the foundation

raise money each year at their annual banquet. She also brings Zarate to the set whenever she can. “My buddy @zarateisaiah came to visit me again @bigbangtheory_cbs ! Adore him! 💕 #ebkids

#findacure 🦋,” she posted in April 2017.