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A STUDY REVEALED THAT LOW VITAMIN D LEVELS ARE LINKED TO INCREASED INFLAMMATION, POTENTIALLY INCREASING THE RISK OF CHRONIC DISEASES. BOOSTING VITAMIN D IN DEFICIENT INDIVIDUALS MAY HELP
REDUCE INFLAMMATION AND PREVENT RELATED HEALTH COMPLICATIONS. Inflammation is actually an essential part of the body’s healing process. However, when it persists, it can contribute to a wide
range of complex diseases including type 2 diabetes, heart disease, and autoimmune diseases. Now, world-first genetic research shows a direct link between low levels of vitamin D and high
levels of inflammation. This finding provides an important biomarker to identify people at higher risk of or severity of chronic illnesses with an inflammatory component. The study, from the
University of South Australia (UniSA), examined the genetic data of 294,970 participants in the UK Biobank. It used Mendelian randomization to show the association between vitamin D and
C-reactive protein levels, an indicator of inflammation. REDUCING CHRONIC INFLAMMATION BY BOOSTING VITAMIN D LEVELS UniSA’s Dr. Ang Zhou, lead researcher, says the findings suggest that
boosting vitamin D in people with a deficiency may reduce chronic inflammation. “Inflammation is your body’s way of protecting your tissues if you’ve been injured or have an infection,” Dr.
Zhou says. “High levels of C-reactive protein are generated by the liver in response to inflammation, so when your body is experiencing chronic inflammation, it also shows higher levels of
C-reactive protein. “This study examined vitamin D and C-reactive proteins and found a one-way relationship between low levels of vitamin D and high levels of C-reactive protein, expressed
as inflammation. “Boosting vitamin D in people with deficiencies may reduce chronic inflammation, helping them avoid a number of related diseases.” IMPLICATIONS FOR REDUCING DISEASE RISK AND
OBESITY COMPLICATIONS The study also raises the possibility that having adequate vitamin D concentrations may mitigate complications arising from obesity and reduce the risk or severity of
chronic illnesses with an inflammatory component, such as cardiovascular diseases, diabetes, and autoimmune diseases. The research was supported by the National Health and Medical Research
Council and published in the _International Journal of Epidemiology_. Professor Elina Hyppönen, senior investigator and Director of UniSA’s Australian Center for Precision Health, says these
results are important and provide an explanation for some of the controversies in reported associations with vitamin D. “We have repeatedly seen evidence for health benefits for increasing
vitamin D concentrations in individuals with very low levels, while for others, there appears to be little to no benefit.” Prof Hyppönen says. “These findings highlight the importance of
avoiding clinical vitamin D deficiency, and provide further evidence for the wide-ranging effects of hormonal vitamin D.” Reference: “Vitamin D deficiency and C-reactive protein: a
bidirectional Mendelian randomization study” by Ang Zhou and Elina Hyppönen, 17 May 2022, _International Journal of Epidemiology_. DOI: 10.1093/ije/dyac087 NEVER MISS A BREAKTHROUGH: JOIN
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