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ABSTRACT The increased expression of G1 cyclins has been associated with the many types of human tumors. In primary solid tumors however, the expression and activity of cyclin E2, the newest
member of the G1 cyclin family, is largely unknown. In this study we have analysed the expression of the E-type cyclins in primary solid tumors from breast, lung, uterus, ovary, colon, and
rectal tissues. Relative gene expression was analysed by quantitative real-time reverse transcription polymerase chain reaction (Taqman). The levels of cyclin E1 and cyclin E2 were
significantly elevated (23 _vs_ 38%, respectively) in primary breast tumor samples relative to normal breast tissue controls. We also observed an inverse correlation between the expression
of cyclin E1/E2 and estrogen receptor in breast tumors. Our results demonstrate that the expression and associated catalytic activity for both cyclin E1 and cyclin E2 is elevated in primary
breast tumors when compared to normal breast tissue. The increased level of cyclin E2 in breast tumors suggests that, similar to cyclin E1, it may contribute to the pathogenesis of breast
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ACKNOWLEDGEMENTS We are particularly grateful to Dennis Slamon (UCLA) for providing many of the breast tumor tissue RNAs. We thank Peter Yakowec for proofreading the manuscript and
providing critical feedback. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Cancer Biology, Amgen Inc., Thousand Oaks, 91320, California, CA, USA Marc Payton, Grace Chung &
Steve Coats * Department of Pathology, Amgen Inc., Thousand Oaks, 91320, California, CA, USA Shelia Scully Authors * Marc Payton View author publications You can also search for this author
inPubMed Google Scholar * Shelia Scully View author publications You can also search for this author inPubMed Google Scholar * Grace Chung View author publications You can also search for
this author inPubMed Google Scholar * Steve Coats View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Steve Coats.
RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Payton, M., Scully, S., Chung, G. _et al._ Deregulation of Cyclin E2 expression and associated kinase
activity in primary breast tumors. _Oncogene_ 21, 8529–8534 (2002). https://doi.org/10.1038/sj.onc.1206035 Download citation * Received: 21 June 2002 * Revised: 30 August 2002 * Accepted: 05
September 2002 * Published: 04 December 2002 * Issue Date: 05 December 2002 * DOI: https://doi.org/10.1038/sj.onc.1206035 SHARE THIS ARTICLE Anyone you share the following link with will be
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initiative KEYWORDS * Cyclin E2 * Cyclin E1 * Cdk2 * breast tumor