ABSTRACT The diverse cellular and biological functions of the nuclear factor kappa B (NF-_κ_B) pathway, together with the catastrophic consequences of its aberrant regulation, demand

specific and highly regulated control of its activity. As described in this review, regulation of the NF-_κ_B pathway is brought about through multiple post-translational modifications that

control the activity of the core components of NF-_κ_B signaling: the I_κ_B kinase (IKK) complex, the I_κ_B proteins and the NF-_κ_B subunits themselves. These regulatory modifications,

which include phosphorylation, ubiquitination, acetylation, sumoylation and nitrosylation, can vary, depending on the nature of the NF-_κ_B-inducing stimulus. Moreover, they frequently have

prognostic biomarkers for many pathological conditions. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS

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CANCER, AND BEYOND Article 13 January 2021 SIGNALLING MECHANISMS AND CELLULAR FUNCTIONS OF SUMO Article 24 June 2022 NF-ΚB IN BIOLOGY AND TARGETED THERAPY: NEW INSIGHTS AND TRANSLATIONAL

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putting together in this review paper, I am aware of how much easier this has been as a result of the excellent and comprehensive reviews on related topics written by many of my colleagues.

I have tried to cite all of these reviews in this manuscript, together with the primary literature. My apologies to any reports I was unable to cite either due to lack of space or my

oversight. Thanks to Drs Cameron Bracken, Kirsteen Campbell and Sonia Rocha for their critical reading of the manuscript. Analysis and numbering of subunit domain structure was aided by

online tools provided by the European Bioinformatics Institute (www.ebi.ac.uk) and DNADyNAmo software (www.bluetractorsoftware.co.uk). Research in the author's laboratory is supported

by a programme grant from Cancer Research UK (C1443/A5435) together with funding from the Association of International Cancer Research (AICR) and the Wellcome Trust. AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Division of Gene Regulation and Expression, University of Dundee, Dundee, Scotland, UK N D Perkins Authors * N D Perkins View author publications You can also

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Perkins, N. Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. _Oncogene_ 25, 6717–6730 (2006).

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Springer Nature SharedIt content-sharing initiative KEYWORDS * NF-_κ_B * IKK * I_κ_B * phosphorylation * ubiquitination * modification