Alcohol drinking and risk of small for gestational age birth

Alcohol drinking and risk of small for gestational age birth

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ABSTRACT OBJECTIVE: To assess if alcohol drinking is a risk factor for small for gestational age (SGA) birth. METHODS: Case–control study. Cases were 555 women (mean age 31 years, range 16–43) who delivered SGA babies at the Clinica Luigi Mangiagalli and the Obstetric and Gynecology Clinic of the University of Verona. The controls were 1966 women (mean age 31 years, range 14–43) who gave birth at term (⩾37 weeks of gestation) to healthy infants of normal weight at the hospitals where cases had been identified. RESULTS: No increase in the risk of SGA birth was observed in women drinking one or two drinks/day in pregnancy, but three or more per day increased the risk: odds ratios (OR) were 3.2 (1.7–6.2) for ⩾3 drinks during the first trimester, 2.7 (1.4–5.3) during the second and 2.9 (1.5–5.7) during the third. CONCLUSIONS: The study shows an increased risk of SGA births in mothers who drink ⩾3 units/day of alcohol in pregnancy. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS MATERNAL ALCOHOL CONSUMPTION AND RISK OF OFFSPRING WITH CONGENITAL MALFORMATION: THE JAPAN ENVIRONMENT AND CHILDREN’S STUDY Article Open access 23 November 2020 PRENATAL ALCOHOL EXPOSURE AND ADVERSE FETAL GROWTH RESTRICTION: FINDINGS FROM THE JAPAN ENVIRONMENT AND CHILDREN’S STUDY Article 04 June 2021 RISK STRATIFICATION FOR SMALL FOR GESTATIONAL AGE FOR THE BRAZILIAN POPULATION: A SECONDARY ANALYSIS OF THE BIRTH IN BRAZIL STUDY Article Open access 07 September 2020 REFERENCES * Abel EL (1982). Consumption of alcohol during pregnancy: a review of effects on growth and development of offpring. _Hum Biol_ 54, 421–453. CAS  PubMed  Google Scholar  * Breslow NE, Day NE (1980). _Statistical Methods in Cancer Research. The Analysis of Case Control Studies_, IARC Publication No. 32, vol. I. IARC: Lyon, France. Google Scholar  * Day NL, Jasperse D, Richardson G, Robles N, Sambamoorthi U, Taylor P _et al_. (1989). Prenatal exposure to alcohol: effect on infant growth and morphologic characteristics. _Pediatrics_ 84, 536–541. CAS  PubMed  Google Scholar  * D'Avanzo B, La Vecchia C, Katsouyanni K, Negri E, Trichopoulos D (1997). An assessment, and reproducibility of food frequency data provided by hospital controls. _Eur J Cancer Prev_ 6, 288–293. Article  CAS  Google Scholar  * Delgado-Rodriguez M, Gomez-Olmedo M, Bueno-Cavanillas A, Garcia-Martin M, Galvez-Vargas R (1995). Recall bias in a case–control study of low birth weight. _J Clin Epidemiol_ 48, 1133–1140. Article  CAS  Google Scholar  * Faden VB, Graubard BL (1994). Alcohol consumption during pregnancy and infant birth weight. _Ann Epidemiol_ 4, 279–284. Article  CAS  Google Scholar  * IARC monographs on evaluation of carcinogenic risks to human (1988). _Alcohol Drinking_, vol. 44 Lyon, France. * Lundsberg LS, Bracken MB, Saftlas AF (1997). Low-to-moderate gestational alcohol use and intrauterine growth retardation, low birthweight, and preterm delivery. _Ann Epidemiol_ 7, 498–508. Article  CAS  Google Scholar  * McDonald AD, Armstrong BG, Sloan M (1992). Cigarette, alcohol, and coffee consumption and prematurity. _Am J Public Health_ 1992, 82:87–82:90. Google Scholar  * Oulette EM, Rosett HL, Rosman P, Weiner L (1977). Adverse effects on offspring of maternal alcohol abuse during pregnancy. _N Engl J Med_ 297, 528–530. Article  Google Scholar  * Parazzini F, Cortinovis I, Bortolus R, Fedele L, Decarli A (1995). Weight at birth by gestational age in Italy. _Hum Reprod_ 10, 1862–1963. Article  CAS  Google Scholar  * Passaro KT, Little RE, Savitz DA, Noss J, ALSPAC Study Team (1996). The effect of maternal drinking before conception and in early pregnancy on infant birthweight. _Epidemiology_ 7, 377–383. Article  CAS  Google Scholar  * Shu XO, Hatch MC, Mills J, Clemens J, Susser M (1995). Maternal smoking, alcohol drinking, caffeine consumpion, and fetal growth: results from a prospective study. _Epidemiology_ 6, 115–120. Article  CAS  Google Scholar  * Sulaiman ND, Florey CD, Taylor DJ, Ogston SA (1988). Alcohol consumption in Dundee primigravidas and its effects on outcome of pregnancy. _BMJ_ 296, 1500–1503. Article  CAS  Google Scholar  * Whitehead N, Lipscomb L (2003). Patterns of alcohol use before and during pregnancy and the risk of small for gestational age birth. _Am J Epidemiol_ 158, 654–662. Article  Google Scholar  * Windham GC, Fenster L, Hopkins B, Swan SH (1995). The association of moderate maternal and paternal alcohol consumption with birthweight and gestational age. _Epidemiology_ 6, 591–597. Article  CAS  Google Scholar  * Yang Q, Witkiewicz BB, Olney RS, Liu Y, Davis M, Khoury MJ _et al_. (2001). A case–control study of maternal alcohol consumption and intrauterine growth retardation. _Ann Epidemiol_ 11, 497–503. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milano, Italy F Chiaffarino, F Parazzini, L Chatenoud & S Cipriani * II Clinica Ostetrico Ginecologica, Università di Milano, Milano, Italy F Parazzini, E Ricci, F Sandretti & L Fedele * Dipartimento di Scienze Ginecologiche, Università La Sapienza, Rome, Italy D Caserta Authors * F Chiaffarino View author publications You can also search for this author inPubMed Google Scholar * F Parazzini View author publications You can also search for this author inPubMed Google Scholar * L Chatenoud View author publications You can also search for this author inPubMed Google Scholar * E Ricci View author publications You can also search for this author inPubMed Google Scholar * F Sandretti View author publications You can also search for this author inPubMed Google Scholar * S Cipriani View author publications You can also search for this author inPubMed Google Scholar * D Caserta View author publications You can also search for this author inPubMed Google Scholar * L Fedele View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to F Parazzini. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Chiaffarino, F., Parazzini, F., Chatenoud, L. _et al._ Alcohol drinking and risk of small for gestational age birth. _Eur J Clin Nutr_ 60, 1062–1066 (2006). https://doi.org/10.1038/sj.ejcn.1602419 Download citation * Received: 11 April 2005 * Revised: 21 December 2005 * Accepted: 11 January 2006 * Published: 22 February 2006 * Issue Date: 01 September 2006 * DOI: https://doi.org/10.1038/sj.ejcn.1602419 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * small for gestational age birth * alcohol * case–control study

ABSTRACT OBJECTIVE: To assess if alcohol drinking is a risk factor for small for gestational age (SGA) birth. METHODS: Case–control study. Cases were 555 women (mean age 31 years, range


16–43) who delivered SGA babies at the Clinica Luigi Mangiagalli and the Obstetric and Gynecology Clinic of the University of Verona. The controls were 1966 women (mean age 31 years, range


14–43) who gave birth at term (⩾37 weeks of gestation) to healthy infants of normal weight at the hospitals where cases had been identified. RESULTS: No increase in the risk of SGA birth was


observed in women drinking one or two drinks/day in pregnancy, but three or more per day increased the risk: odds ratios (OR) were 3.2 (1.7–6.2) for ⩾3 drinks during the first trimester,


2.7 (1.4–5.3) during the second and 2.9 (1.5–5.7) during the third. CONCLUSIONS: The study shows an increased risk of SGA births in mothers who drink ⩾3 units/day of alcohol in pregnancy.


Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this


journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now


Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer


support SIMILAR CONTENT BEING VIEWED BY OTHERS MATERNAL ALCOHOL CONSUMPTION AND RISK OF OFFSPRING WITH CONGENITAL MALFORMATION: THE JAPAN ENVIRONMENT AND CHILDREN’S STUDY Article Open access


23 November 2020 PRENATAL ALCOHOL EXPOSURE AND ADVERSE FETAL GROWTH RESTRICTION: FINDINGS FROM THE JAPAN ENVIRONMENT AND CHILDREN’S STUDY Article 04 June 2021 RISK STRATIFICATION FOR SMALL


FOR GESTATIONAL AGE FOR THE BRAZILIAN POPULATION: A SECONDARY ANALYSIS OF THE BIRTH IN BRAZIL STUDY Article Open access 07 September 2020 REFERENCES * Abel EL (1982). Consumption of alcohol


during pregnancy: a review of effects on growth and development of offpring. _Hum Biol_ 54, 421–453. CAS  PubMed  Google Scholar  * Breslow NE, Day NE (1980). _Statistical Methods in Cancer


Research. The Analysis of Case Control Studies_, IARC Publication No. 32, vol. I. IARC: Lyon, France. Google Scholar  * Day NL, Jasperse D, Richardson G, Robles N, Sambamoorthi U, Taylor P


_et al_. (1989). Prenatal exposure to alcohol: effect on infant growth and morphologic characteristics. _Pediatrics_ 84, 536–541. CAS  PubMed  Google Scholar  * D'Avanzo B, La Vecchia


C, Katsouyanni K, Negri E, Trichopoulos D (1997). An assessment, and reproducibility of food frequency data provided by hospital controls. _Eur J Cancer Prev_ 6, 288–293. Article  CAS 


Google Scholar  * Delgado-Rodriguez M, Gomez-Olmedo M, Bueno-Cavanillas A, Garcia-Martin M, Galvez-Vargas R (1995). Recall bias in a case–control study of low birth weight. _J Clin


Epidemiol_ 48, 1133–1140. Article  CAS  Google Scholar  * Faden VB, Graubard BL (1994). Alcohol consumption during pregnancy and infant birth weight. _Ann Epidemiol_ 4, 279–284. Article  CAS


  Google Scholar  * IARC monographs on evaluation of carcinogenic risks to human (1988). _Alcohol Drinking_, vol. 44 Lyon, France. * Lundsberg LS, Bracken MB, Saftlas AF (1997).


Low-to-moderate gestational alcohol use and intrauterine growth retardation, low birthweight, and preterm delivery. _Ann Epidemiol_ 7, 498–508. Article  CAS  Google Scholar  * McDonald AD,


Armstrong BG, Sloan M (1992). Cigarette, alcohol, and coffee consumption and prematurity. _Am J Public Health_ 1992, 82:87–82:90. Google Scholar  * Oulette EM, Rosett HL, Rosman P, Weiner L


(1977). Adverse effects on offspring of maternal alcohol abuse during pregnancy. _N Engl J Med_ 297, 528–530. Article  Google Scholar  * Parazzini F, Cortinovis I, Bortolus R, Fedele L,


Decarli A (1995). Weight at birth by gestational age in Italy. _Hum Reprod_ 10, 1862–1963. Article  CAS  Google Scholar  * Passaro KT, Little RE, Savitz DA, Noss J, ALSPAC Study Team (1996).


The effect of maternal drinking before conception and in early pregnancy on infant birthweight. _Epidemiology_ 7, 377–383. Article  CAS  Google Scholar  * Shu XO, Hatch MC, Mills J, Clemens


J, Susser M (1995). Maternal smoking, alcohol drinking, caffeine consumpion, and fetal growth: results from a prospective study. _Epidemiology_ 6, 115–120. Article  CAS  Google Scholar  *


Sulaiman ND, Florey CD, Taylor DJ, Ogston SA (1988). Alcohol consumption in Dundee primigravidas and its effects on outcome of pregnancy. _BMJ_ 296, 1500–1503. Article  CAS  Google Scholar 


* Whitehead N, Lipscomb L (2003). Patterns of alcohol use before and during pregnancy and the risk of small for gestational age birth. _Am J Epidemiol_ 158, 654–662. Article  Google Scholar


  * Windham GC, Fenster L, Hopkins B, Swan SH (1995). The association of moderate maternal and paternal alcohol consumption with birthweight and gestational age. _Epidemiology_ 6, 591–597.


Article  CAS  Google Scholar  * Yang Q, Witkiewicz BB, Olney RS, Liu Y, Davis M, Khoury MJ _et al_. (2001). A case–control study of maternal alcohol consumption and intrauterine growth


retardation. _Ann Epidemiol_ 11, 497–503. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Istituto di Ricerche Farmacologiche ‘Mario Negri’,


Milano, Italy F Chiaffarino, F Parazzini, L Chatenoud & S Cipriani * II Clinica Ostetrico Ginecologica, Università di Milano, Milano, Italy F Parazzini, E Ricci, F Sandretti & L


Fedele * Dipartimento di Scienze Ginecologiche, Università La Sapienza, Rome, Italy D Caserta Authors * F Chiaffarino View author publications You can also search for this author inPubMed 


Google Scholar * F Parazzini View author publications You can also search for this author inPubMed Google Scholar * L Chatenoud View author publications You can also search for this author


inPubMed Google Scholar * E Ricci View author publications You can also search for this author inPubMed Google Scholar * F Sandretti View author publications You can also search for this


author inPubMed Google Scholar * S Cipriani View author publications You can also search for this author inPubMed Google Scholar * D Caserta View author publications You can also search for


this author inPubMed Google Scholar * L Fedele View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to F Parazzini. RIGHTS


AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Chiaffarino, F., Parazzini, F., Chatenoud, L. _et al._ Alcohol drinking and risk of small for gestational age


birth. _Eur J Clin Nutr_ 60, 1062–1066 (2006). https://doi.org/10.1038/sj.ejcn.1602419 Download citation * Received: 11 April 2005 * Revised: 21 December 2005 * Accepted: 11 January 2006 *


Published: 22 February 2006 * Issue Date: 01 September 2006 * DOI: https://doi.org/10.1038/sj.ejcn.1602419 SHARE THIS ARTICLE Anyone you share the following link with will be able to read


this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative


KEYWORDS * small for gestational age birth * alcohol * case–control study