Congeners of pempidine with high ganglion-blocking activity

Congeners of pempidine with high ganglion-blocking activity

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ABSTRACT RESEARCH in these Laboratories on new hypotensive drugs has in recent years centred on the development of compounds exhibiting both a high level of ganglion-blocking activity and good absorption after oral administration. The first phase of this work culminated in the discovery of 1:2:2:6:6:-pentamethylpiperidine, pempidine1. In clinical use the good absorption and conveniently rapid excretion characteristics of this drug combine to make it a useful advance in the management of essential hypertension2. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ANTIHYPERTENSIVE EFFECT OF _SINAPINE_ EXTRACTED FROM RAPESEED MEAL IN 2K1C HYPERTENSIVE RATS Article Open access 03 February 2025 NOVEL ANTIHYPERTENSIVE AGENTS FOR RESISTANT HYPERTENSION: WHAT DOES THE FUTURE HOLD? Article 27 September 2022 PHARMACOLOGICAL CHARACTERIZATION OF MT-1207, A NOVEL MULTITARGET ANTIHYPERTENSIVE AGENT Article 29 March 2021 REFERENCES * Lee, G. E., Wragg, W. R., Corne, S. J., Edge, N. D., and Reading, H. W., _Nature_, 181, 1717 (1958). Corne, S. J., and Edge, N. D., _Brit. J. Pharmacol._, 13, 339 (1958). The independent discovery of the ganglion-blocking activity of 1:2:2:6:6-pentamethylpiperidine by an entirely different approach has also been reported by Spinks, A., and Young, E. H. P., _Nature_, 181, 1397 (1958). Spinks, A., Young, E. H. P., Farrington, J. A., and Dunlop, D., _Brit. J. Pharmacol._, 13, 501 (1958). Article  ADS  CAS  Google Scholar  * Harington, M., Kincaid-Smith, P., and Milne, M. D., _Lancet_, ii, 6 (1958). * Gyermek, L., and Nádor, K., _J. Pharm. Pharmacol._, 9, 209 (1957). Article  CAS  Google Scholar  * Naylor, R. F., _J. Chem. Soc._, 1106 (1947). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Chemical Research Laboratories, L. BRETHERICK, G. E. LEE, E. LUNT & W. R. WRAGG * Biological Research Laboratories, May and Baker, Ltd., Dagenham N. D. EDGE Authors * L. BRETHERICK View author publications You can also search for this author inPubMed Google Scholar * G. E. LEE View author publications You can also search for this author inPubMed Google Scholar * E. LUNT View author publications You can also search for this author inPubMed Google Scholar * W. R. WRAGG View author publications You can also search for this author inPubMed Google Scholar * N. D. EDGE View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE BRETHERICK, L., LEE, G., LUNT, E. _et al._ Congeners of Pempidine with High Ganglion-blocking Activity. _Nature_ 184, 1707–1709 (1959). https://doi.org/10.1038/1841707a0 Download citation * Issue Date: 28 November 1959 * DOI: https://doi.org/10.1038/1841707a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT RESEARCH in these Laboratories on new hypotensive drugs has in recent years centred on the development of compounds exhibiting both a high level of ganglion-blocking activity and


good absorption after oral administration. The first phase of this work culminated in the discovery of 1:2:2:6:6:-pentamethylpiperidine, pempidine1. In clinical use the good absorption and


conveniently rapid excretion characteristics of this drug combine to make it a useful advance in the management of essential hypertension2. Access through your institution Buy or subscribe


This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access


$199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are


calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS


ANTIHYPERTENSIVE EFFECT OF _SINAPINE_ EXTRACTED FROM RAPESEED MEAL IN 2K1C HYPERTENSIVE RATS Article Open access 03 February 2025 NOVEL ANTIHYPERTENSIVE AGENTS FOR RESISTANT HYPERTENSION:


WHAT DOES THE FUTURE HOLD? Article 27 September 2022 PHARMACOLOGICAL CHARACTERIZATION OF MT-1207, A NOVEL MULTITARGET ANTIHYPERTENSIVE AGENT Article 29 March 2021 REFERENCES * Lee, G. E.,


Wragg, W. R., Corne, S. J., Edge, N. D., and Reading, H. W., _Nature_, 181, 1717 (1958). Corne, S. J., and Edge, N. D., _Brit. J. Pharmacol._, 13, 339 (1958). The independent discovery of


the ganglion-blocking activity of 1:2:2:6:6-pentamethylpiperidine by an entirely different approach has also been reported by Spinks, A., and Young, E. H. P., _Nature_, 181, 1397 (1958).


Spinks, A., Young, E. H. P., Farrington, J. A., and Dunlop, D., _Brit. J. Pharmacol._, 13, 501 (1958). Article  ADS  CAS  Google Scholar  * Harington, M., Kincaid-Smith, P., and Milne, M.


D., _Lancet_, ii, 6 (1958). * Gyermek, L., and Nádor, K., _J. Pharm. Pharmacol._, 9, 209 (1957). Article  CAS  Google Scholar  * Naylor, R. F., _J. Chem. Soc._, 1106 (1947). Download


references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Chemical Research Laboratories, L. BRETHERICK, G. E. LEE, E. LUNT & W. R. WRAGG * Biological Research Laboratories, May and


Baker, Ltd., Dagenham N. D. EDGE Authors * L. BRETHERICK View author publications You can also search for this author inPubMed Google Scholar * G. E. LEE View author publications You can


also search for this author inPubMed Google Scholar * E. LUNT View author publications You can also search for this author inPubMed Google Scholar * W. R. WRAGG View author publications You


can also search for this author inPubMed Google Scholar * N. D. EDGE View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE BRETHERICK, L., LEE, G., LUNT, E. _et al._ Congeners of Pempidine with High Ganglion-blocking Activity. _Nature_ 184, 1707–1709 (1959).


https://doi.org/10.1038/1841707a0 Download citation * Issue Date: 28 November 1959 * DOI: https://doi.org/10.1038/1841707a0 SHARE THIS ARTICLE Anyone you share the following link with will


be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt


content-sharing initiative