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ABSTRACT RESEARCH in these Laboratories on new hypotensive drugs has in recent years centred on the development of compounds exhibiting both a high level of ganglion-blocking activity and
good absorption after oral administration. The first phase of this work culminated in the discovery of 1:2:2:6:6:-pentamethylpiperidine, pempidine1. In clinical use the good absorption and
conveniently rapid excretion characteristics of this drug combine to make it a useful advance in the management of essential hypertension2. Access through your institution Buy or subscribe
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ANTIHYPERTENSIVE EFFECT OF _SINAPINE_ EXTRACTED FROM RAPESEED MEAL IN 2K1C HYPERTENSIVE RATS Article Open access 03 February 2025 NOVEL ANTIHYPERTENSIVE AGENTS FOR RESISTANT HYPERTENSION:
WHAT DOES THE FUTURE HOLD? Article 27 September 2022 PHARMACOLOGICAL CHARACTERIZATION OF MT-1207, A NOVEL MULTITARGET ANTIHYPERTENSIVE AGENT Article 29 March 2021 REFERENCES * Lee, G. E.,
Wragg, W. R., Corne, S. J., Edge, N. D., and Reading, H. W., _Nature_, 181, 1717 (1958). Corne, S. J., and Edge, N. D., _Brit. J. Pharmacol._, 13, 339 (1958). The independent discovery of
the ganglion-blocking activity of 1:2:2:6:6-pentamethylpiperidine by an entirely different approach has also been reported by Spinks, A., and Young, E. H. P., _Nature_, 181, 1397 (1958).
Spinks, A., Young, E. H. P., Farrington, J. A., and Dunlop, D., _Brit. J. Pharmacol._, 13, 501 (1958). Article ADS CAS Google Scholar * Harington, M., Kincaid-Smith, P., and Milne, M.
D., _Lancet_, ii, 6 (1958). * Gyermek, L., and Nádor, K., _J. Pharm. Pharmacol._, 9, 209 (1957). Article CAS Google Scholar * Naylor, R. F., _J. Chem. Soc._, 1106 (1947). Download
references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Chemical Research Laboratories, L. BRETHERICK, G. E. LEE, E. LUNT & W. R. WRAGG * Biological Research Laboratories, May and
Baker, Ltd., Dagenham N. D. EDGE Authors * L. BRETHERICK View author publications You can also search for this author inPubMed Google Scholar * G. E. LEE View author publications You can
also search for this author inPubMed Google Scholar * E. LUNT View author publications You can also search for this author inPubMed Google Scholar * W. R. WRAGG View author publications You
can also search for this author inPubMed Google Scholar * N. D. EDGE View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and
permissions ABOUT THIS ARTICLE CITE THIS ARTICLE BRETHERICK, L., LEE, G., LUNT, E. _et al._ Congeners of Pempidine with High Ganglion-blocking Activity. _Nature_ 184, 1707–1709 (1959).
https://doi.org/10.1038/1841707a0 Download citation * Issue Date: 28 November 1959 * DOI: https://doi.org/10.1038/1841707a0 SHARE THIS ARTICLE Anyone you share the following link with will
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