Intracellular response to an iso-immune reaction at the surface of ascites tumour cells

Intracellular response to an iso-immune reaction at the surface of ascites tumour cells

Play all audios:

Loading...

ABSTRACT THE cytotoxic effect on mouse ascites tumour cells treated _in vitro_ with various antibodies has been shown to require the presence of complement1,2. In the absence of complement the cells appear to be normal when viewed by phase contrast microscopy3; they retain their capacity to exclude trypan blue2 and to metabolize glucose4. The only changes which have been reported are slight alterations in the fine structure of the cell surface, which were thought to favour agglutination by rabbit antibody directed against ascites cells3. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS DIRECT ADMINISTRATION OF HUMAN LEUCOCYTE ANTIGEN (DHLA) MOLECULES INTO TUMOUR SITES: PROPOSAL FOR A NEW IMMUNOTHERAPY FOR CANCER Article Open access 23 October 2023 ABO BLOOD GROUP ANTIGEN THERAPY: A POTENTIAL NEW STRATEGY AGAINST SOLID TUMORS Article Open access 10 August 2021 NATURAL KILLER CELLS AT THE FRONTLINE IN THE FIGHT AGAINST CANCER Article Open access 23 August 2024 REFERENCES * Wissler, R. W., and Flax, M. H., _Ann. N.Y. Acad. Sci._, 69, 773 (1957). Article  ADS  CAS  PubMed  Google Scholar  * Gorer, P. A., and O'Gorman, P., _Transplantation Bull._, 3, 142 (1956). Google Scholar  * Goldberg, B., and Green, H., _J. Exp. Med._, 109, 505 (1959). Article  CAS  PubMed  PubMed Central  Google Scholar  * Bickis, I. J., Quastel, J. H., and Vas, S. I., _Cancer Res._, 19, 602 (1959). CAS  PubMed  Google Scholar  * Gorer, P. A., _Adv. Cancer Res._, 4, 149 (1956). Article  CAS  PubMed  Google Scholar  * Snell, G. D., _J. Genet._, 49, 87 (1948). Article  CAS  PubMed  Google Scholar  * Bitensky, L., _Quart. J. Micro. Sci._ (in the press). * Baker, J. R., _Quart. J. Micro. Sci._, 87, 441 (1946). CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Medical Research Council Rheumatism Research Unit, Canadian Red Cross Memorial Hospital, Taplow, Maidenhead, Berks D. C. DUMONDE & CLARICE M. WALTER * Department of Pathology, Royal College of Surgeons, Lincoln's Inn Fields, London, W.C.2 LUCILLE BITENSKY, G. J. CUNNINGHAM & J. CHAYEN Authors * D. C. DUMONDE View author publications You can also search for this author inPubMed Google Scholar * CLARICE M. WALTER View author publications You can also search for this author inPubMed Google Scholar * LUCILLE BITENSKY View author publications You can also search for this author inPubMed Google Scholar * G. J. CUNNINGHAM View author publications You can also search for this author inPubMed Google Scholar * J. CHAYEN View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE DUMONDE, D., WALTER, C., BITENSKY, L. _et al._ Intracellular Response to an Iso-immune Reaction at the Surface of Ascites Tumour Cells. _Nature_ 192, 1302 (1961). https://doi.org/10.1038/1921302a0 Download citation * Issue Date: 30 December 1961 * DOI: https://doi.org/10.1038/1921302a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT THE cytotoxic effect on mouse ascites tumour cells treated _in vitro_ with various antibodies has been shown to require the presence of complement1,2. In the absence of complement


the cells appear to be normal when viewed by phase contrast microscopy3; they retain their capacity to exclude trypan blue2 and to metabolize glucose4. The only changes which have been


reported are slight alterations in the fine structure of the cell surface, which were thought to favour agglutination by rabbit antibody directed against ascites cells3. Access through your


institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print


issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to


local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT


BEING VIEWED BY OTHERS DIRECT ADMINISTRATION OF HUMAN LEUCOCYTE ANTIGEN (DHLA) MOLECULES INTO TUMOUR SITES: PROPOSAL FOR A NEW IMMUNOTHERAPY FOR CANCER Article Open access 23 October 2023


ABO BLOOD GROUP ANTIGEN THERAPY: A POTENTIAL NEW STRATEGY AGAINST SOLID TUMORS Article Open access 10 August 2021 NATURAL KILLER CELLS AT THE FRONTLINE IN THE FIGHT AGAINST CANCER Article


Open access 23 August 2024 REFERENCES * Wissler, R. W., and Flax, M. H., _Ann. N.Y. Acad. Sci._, 69, 773 (1957). Article  ADS  CAS  PubMed  Google Scholar  * Gorer, P. A., and O'Gorman,


P., _Transplantation Bull._, 3, 142 (1956). Google Scholar  * Goldberg, B., and Green, H., _J. Exp. Med._, 109, 505 (1959). Article  CAS  PubMed  PubMed Central  Google Scholar  * Bickis,


I. J., Quastel, J. H., and Vas, S. I., _Cancer Res._, 19, 602 (1959). CAS  PubMed  Google Scholar  * Gorer, P. A., _Adv. Cancer Res._, 4, 149 (1956). Article  CAS  PubMed  Google Scholar  *


Snell, G. D., _J. Genet._, 49, 87 (1948). Article  CAS  PubMed  Google Scholar  * Bitensky, L., _Quart. J. Micro. Sci._ (in the press). * Baker, J. R., _Quart. J. Micro. Sci._, 87, 441


(1946). CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Medical Research Council Rheumatism Research Unit, Canadian Red Cross Memorial Hospital,


Taplow, Maidenhead, Berks D. C. DUMONDE & CLARICE M. WALTER * Department of Pathology, Royal College of Surgeons, Lincoln's Inn Fields, London, W.C.2 LUCILLE BITENSKY, G. J.


CUNNINGHAM & J. CHAYEN Authors * D. C. DUMONDE View author publications You can also search for this author inPubMed Google Scholar * CLARICE M. WALTER View author publications You can


also search for this author inPubMed Google Scholar * LUCILLE BITENSKY View author publications You can also search for this author inPubMed Google Scholar * G. J. CUNNINGHAM View author


publications You can also search for this author inPubMed Google Scholar * J. CHAYEN View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND


PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE DUMONDE, D., WALTER, C., BITENSKY, L. _et al._ Intracellular Response to an Iso-immune Reaction at the Surface of


Ascites Tumour Cells. _Nature_ 192, 1302 (1961). https://doi.org/10.1038/1921302a0 Download citation * Issue Date: 30 December 1961 * DOI: https://doi.org/10.1038/1921302a0 SHARE THIS


ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard


Provided by the Springer Nature SharedIt content-sharing initiative