Correlation of loss of hyaluronic acid and chondroitin sulphate in skin of mice with carcass nitrogen loss during starvation

Correlation of loss of hyaluronic acid and chondroitin sulphate in skin of mice with carcass nitrogen loss during starvation

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ABSTRACT THE constituents of the ground substance of connective tissue respond dynamically to loss of systemic nitrogen. Marked changes have been reported to occur in the composition of the skin of mice during starvation1. This is accompanied by a significant reduction in hyaluronic acid (HA) and chondroitin sulphate (CS). Earlier studies2 with rats suggested that hexosamine-containing materials in the skin decreased rapidly with small losses of carcass nitrogen (N), but when large losses occurred the additional decrement in the former was small. No attempt, however, was made to quantitate this relationship. In this work, decrement in HA and CS during starvation was correlated with loss of N in mice. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS EVOLUTION OF HIGH-MOLECULAR-MASS HYALURONIC ACID IS ASSOCIATED WITH SUBTERRANEAN LIFESTYLE Article Open access 05 December 2023 METABOLOMIC ANALYSIS OF SKELETAL MUSCLE BEFORE AND AFTER STRENUOUS EXERCISE TO FATIGUE Article Open access 27 May 2021 EFFECT OF 4-WEEK PHYSICAL EXERCISES ON TRYPTOPHAN, KYNURENINE AND KYNURENIC ACID CONTENT IN HUMAN SWEAT Article Open access 27 May 2021 REFERENCES * Sobel, H., Hewlett, M. J., Hoshek, S., and Sacker, I. M., _Amer. J. Physiol._ 212, 773 (1967). CAS  PubMed  Google Scholar  * Sobel, H., Gabay, S., Johnson, C., and Hassan, B., _Metabolism_, 8, 180 (1959). CAS  PubMed  Google Scholar  * Sobel, H., Lee, K. D., and Hewlett, M. J., _Biochim. Biophys. Acta_, 101, 225 (1965). CAS  PubMed  Google Scholar  * Sobel, H., and Hewlett, M. J., _Proc. Soc. Exp. Biol. and Med._, 126, 149 (1967). Article  CAS  Google Scholar  * Laurent, T. C., and Persson, H., _Biochim. Biophys. Acta_, 78, 360 (1963). Article  CAS  Google Scholar  * Wasserman, K., and Meyerson, H. S., _Amer. J. Physiol._, 165, 15 (1951). CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Aging Research Laboratory, Veterans Administration Hospital, Sepulveda, California H. SOBEL, M. HEWLETT & R. COHEN * School of Public Health, University of California, Los Angeles, Los Angeles, California H. SOBEL, M. HEWLETT & R. COHEN Authors * H. SOBEL View author publications You can also search for this author inPubMed Google Scholar * M. HEWLETT View author publications You can also search for this author inPubMed Google Scholar * R. COHEN View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE SOBEL, H., HEWLETT, M. & COHEN, R. Correlation of Loss of Hyaluronic Acid and Chondroitin Sulphate in Skin of Mice with Carcass Nitrogen Loss during Starvation. _Nature_ 217, 1279–1280 (1968). https://doi.org/10.1038/2171279a0 Download citation * Received: 28 December 1967 * Revised: 09 February 1968 * Issue Date: 30 March 1968 * DOI: https://doi.org/10.1038/2171279a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT THE constituents of the ground substance of connective tissue respond dynamically to loss of systemic nitrogen. Marked changes have been reported to occur in the composition of the


skin of mice during starvation1. This is accompanied by a significant reduction in hyaluronic acid (HA) and chondroitin sulphate (CS). Earlier studies2 with rats suggested that


hexosamine-containing materials in the skin decreased rapidly with small losses of carcass nitrogen (N), but when large losses occurred the additional decrement in the former was small. No


attempt, however, was made to quantitate this relationship. In this work, decrement in HA and CS during starvation was correlated with loss of N in mice. Access through your institution Buy


or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and


online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes


which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY


OTHERS EVOLUTION OF HIGH-MOLECULAR-MASS HYALURONIC ACID IS ASSOCIATED WITH SUBTERRANEAN LIFESTYLE Article Open access 05 December 2023 METABOLOMIC ANALYSIS OF SKELETAL MUSCLE BEFORE AND


AFTER STRENUOUS EXERCISE TO FATIGUE Article Open access 27 May 2021 EFFECT OF 4-WEEK PHYSICAL EXERCISES ON TRYPTOPHAN, KYNURENINE AND KYNURENIC ACID CONTENT IN HUMAN SWEAT Article Open


access 27 May 2021 REFERENCES * Sobel, H., Hewlett, M. J., Hoshek, S., and Sacker, I. M., _Amer. J. Physiol._ 212, 773 (1967). CAS  PubMed  Google Scholar  * Sobel, H., Gabay, S., Johnson,


C., and Hassan, B., _Metabolism_, 8, 180 (1959). CAS  PubMed  Google Scholar  * Sobel, H., Lee, K. D., and Hewlett, M. J., _Biochim. Biophys. Acta_, 101, 225 (1965). CAS  PubMed  Google


Scholar  * Sobel, H., and Hewlett, M. J., _Proc. Soc. Exp. Biol. and Med._, 126, 149 (1967). Article  CAS  Google Scholar  * Laurent, T. C., and Persson, H., _Biochim. Biophys. Acta_, 78,


360 (1963). Article  CAS  Google Scholar  * Wasserman, K., and Meyerson, H. S., _Amer. J. Physiol._, 165, 15 (1951). CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION


AUTHORS AND AFFILIATIONS * Aging Research Laboratory, Veterans Administration Hospital, Sepulveda, California H. SOBEL, M. HEWLETT & R. COHEN * School of Public Health, University of


California, Los Angeles, Los Angeles, California H. SOBEL, M. HEWLETT & R. COHEN Authors * H. SOBEL View author publications You can also search for this author inPubMed Google Scholar *


M. HEWLETT View author publications You can also search for this author inPubMed Google Scholar * R. COHEN View author publications You can also search for this author inPubMed Google


Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE SOBEL, H., HEWLETT, M. & COHEN, R. Correlation of Loss of Hyaluronic Acid and Chondroitin


Sulphate in Skin of Mice with Carcass Nitrogen Loss during Starvation. _Nature_ 217, 1279–1280 (1968). https://doi.org/10.1038/2171279a0 Download citation * Received: 28 December 1967 *


Revised: 09 February 1968 * Issue Date: 30 March 1968 * DOI: https://doi.org/10.1038/2171279a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:


Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative