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ABSTRACT THE constituents of the ground substance of connective tissue respond dynamically to loss of systemic nitrogen. Marked changes have been reported to occur in the composition of the
skin of mice during starvation1. This is accompanied by a significant reduction in hyaluronic acid (HA) and chondroitin sulphate (CS). Earlier studies2 with rats suggested that
hexosamine-containing materials in the skin decreased rapidly with small losses of carcass nitrogen (N), but when large losses occurred the additional decrement in the former was small. No
attempt, however, was made to quantitate this relationship. In this work, decrement in HA and CS during starvation was correlated with loss of N in mice. Access through your institution Buy
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access 27 May 2021 REFERENCES * Sobel, H., Hewlett, M. J., Hoshek, S., and Sacker, I. M., _Amer. J. Physiol._ 212, 773 (1967). CAS PubMed Google Scholar * Sobel, H., Gabay, S., Johnson,
C., and Hassan, B., _Metabolism_, 8, 180 (1959). CAS PubMed Google Scholar * Sobel, H., Lee, K. D., and Hewlett, M. J., _Biochim. Biophys. Acta_, 101, 225 (1965). CAS PubMed Google
Scholar * Sobel, H., and Hewlett, M. J., _Proc. Soc. Exp. Biol. and Med._, 126, 149 (1967). Article CAS Google Scholar * Laurent, T. C., and Persson, H., _Biochim. Biophys. Acta_, 78,
360 (1963). Article CAS Google Scholar * Wasserman, K., and Meyerson, H. S., _Amer. J. Physiol._, 165, 15 (1951). CAS PubMed Google Scholar Download references AUTHOR INFORMATION
AUTHORS AND AFFILIATIONS * Aging Research Laboratory, Veterans Administration Hospital, Sepulveda, California H. SOBEL, M. HEWLETT & R. COHEN * School of Public Health, University of
California, Los Angeles, Los Angeles, California H. SOBEL, M. HEWLETT & R. COHEN Authors * H. SOBEL View author publications You can also search for this author inPubMed Google Scholar *
M. HEWLETT View author publications You can also search for this author inPubMed Google Scholar * R. COHEN View author publications You can also search for this author inPubMed Google
Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE SOBEL, H., HEWLETT, M. & COHEN, R. Correlation of Loss of Hyaluronic Acid and Chondroitin
Sulphate in Skin of Mice with Carcass Nitrogen Loss during Starvation. _Nature_ 217, 1279–1280 (1968). https://doi.org/10.1038/2171279a0 Download citation * Received: 28 December 1967 *
Revised: 09 February 1968 * Issue Date: 30 March 1968 * DOI: https://doi.org/10.1038/2171279a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:
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