ABSTRACT Globus and Kuhlenbeck1,2 drew attention to the presence beneath the lining of the cerebral ventricles of a distinct cell layer, which they named the subependymal cell plate. They

demonstrated it in the brain of human infants, showed it to contain primitive cells and stressed its possible role in the development of certain paraventricular neoplasms. Various workers3–5

have shown the persistence of a subependymal layer in man from foetal to adult life, but except for explaining the origin of “subependymomas”6 the idea that this zone plays a part in the

genesis of gliomas has met with little support. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS A BRAIN PRECURSOR ATLAS REVEALS THE ACQUISITION OF DEVELOPMENTAL-LIKE STATES IN ADULT CEREBRAL

TUMOURS Article Open access 19 July 2022 SINGLE-CELL ATLAS OF EARLY HUMAN BRAIN DEVELOPMENT HIGHLIGHTS HETEROGENEITY OF HUMAN NEUROEPITHELIAL CELLS AND EARLY RADIAL GLIA Article Open access

15 March 2021 HOW MECHANISMS OF STEM CELL POLARITY SHAPE THE HUMAN CEREBRAL CORTEX Article 30 September 2022 REFERENCES * Globus, J. H., and Kuhlenbeck, H., _Arch. Pathol._, 34, 674 (1942).

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MRC Research Group in Applied Neurobiology, Institute of Neurology, Queen Square, London P. D. LEWIS Authors * P. D. LEWIS View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE LEWIS, P. Mitotic Activity in the Primate Subependymal Layer and the Genesis of

Gliomas. _Nature_ 217, 974–975 (1968). https://doi.org/10.1038/217974a0 Download citation * Received: 13 December 1967 * Revised: 12 February 1968 * Issue Date: 09 March 1968 * DOI:

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