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ABSTRACT Diffuse large B cell lymphoma (DLBL) constitutes the greatest percentage of adult non-Hodgkin’s lymphomas and represents a diverse spectrum of lymphoid neoplasms. Clinicopathologic,
phenotypic and genotypic findings were correlated and compared for 63 DLBL cases to investigate whether they represent clinically relevant subtypes. They were all cyclin D1 negative and
were phenotypically divided into three groups, ie group I (CD5+ type, _n_ = 11), group II (CD5− CD10+ type, _n_ = 19), and group III (CD5− CD10− type, _n_ = 33). Data were correlated by
observing the respective gene rearrangement and expression of _BCL2_ and _BCL6_. In clinical aspects, the group I cases demonstrated a significantly inferior survival than those of the other
two groups (log-rank test, _P_ = 0.016). Although rearrangement of _BCL2_ and _BCL6_ did not show any inclination to a specific subgroup, the immunohistochemical detection of BCL2 was less
frequent, at a statistically significant level (_P_ = 0.011), in group II (50%) than in group I (82%) and III (82%) cases. This appears to confirm the unique aspect of the CD5− CD10+ type
DLBL, indicating a certain relationship with the normal germinal center cells which usually lack BCL2 expression. The BCL6 protein expression was detected in most of the present DLBL cases
(92%) irrespective of this grouping. These data suggest that the phenotypic delineation by the detection of CD5 and CD10 will improve our understanding of DLBL and be helpful in a future
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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS BCL2 SUPER-EXPRESSOR DIFFUSE LARGE B-CELL LYMPHOMA: A DISTINCT SUBGROUP ASSOCIATED WITH POOR PROGNOSIS Article 11 November
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OF CSF-CTDNA POSITIVITY IN NEWLY DIAGNOSED DIFFUSE LARGE B CELL LYMPHOMA Article 15 May 2024 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratory of Chemotherapy, Aichi Cancer Center
Research Institute, Japan S Harada, R Suzuki & M Seto * Second Department of Internal Medicine, Nagoya City University School of Medicine, Japan S Harada & R Ueda * Department of
Hematology and Chemotherapy, Aichi Cancer Center Hospital, Japan K Uehira, Y Kagami, M Ogura & Y Morishima * Department of Pathology and Clinical Laboratories, Aichi Cancer Center
Hospital, Japan Y Yatabe & S Nakamura * Department of Internal Medicine, Okazaki Municipal Hospital, Japan H Suzuki * Department of Internal Medicine, Aichi Prefectural Hospital, Japan A
Oyama * Department of Internal Medicine, Japanese Red Cross, Nagoya First Hospital, Japan Y Kodera Authors * S Harada View author publications You can also search for this author inPubMed
Google Scholar * R Suzuki View author publications You can also search for this author inPubMed Google Scholar * K Uehira View author publications You can also search for this author
inPubMed Google Scholar * Y Yatabe View author publications You can also search for this author inPubMed Google Scholar * Y Kagami View author publications You can also search for this
author inPubMed Google Scholar * M Ogura View author publications You can also search for this author inPubMed Google Scholar * H Suzuki View author publications You can also search for this
author inPubMed Google Scholar * A Oyama View author publications You can also search for this author inPubMed Google Scholar * Y Kodera View author publications You can also search for
this author inPubMed Google Scholar * R Ueda View author publications You can also search for this author inPubMed Google Scholar * Y Morishima View author publications You can also search
for this author inPubMed Google Scholar * S Nakamura View author publications You can also search for this author inPubMed Google Scholar * M Seto View author publications You can also
search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Harada, S., Suzuki, R., Uehira, K. _et al._ Molecular and
immunological dissection of diffuse large B cell lymphoma: CD5+, and CD5− with CD10+ groups may constitute clinically relevant subtypes. _Leukemia_ 13, 1441–1447 (1999).
https://doi.org/10.1038/sj.leu.2401487 Download citation * Received: 08 March 1999 * Accepted: 11 May 1999 * Published: 09 September 1999 * Issue Date: 01 September 1999 * DOI:
https://doi.org/10.1038/sj.leu.2401487 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * diffuse large B cell lymphoma * CD5 * CD10 * _BCL2_ *
_BCL6_