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Access through your institution Buy or subscribe TO THE EDITOR Mutations in the mitochondrial genome have been reported in various forms of carcinoma. For acute leukaemia, however, there is
only one definitive report1 of their presence in one patient with acute lymphoblastic leukaemia (ALL), together with another report2 on alteration of restriction fragment length
polymorphisms in ALL cells, which could be interpreted as being due to acquired mutations. We therefore sought mitochondrial mutations in 22 patients with acute myeloid leukaemia (AML) (11
males, 11 females, ages 16–69) and 26 patients with ALL (14 males, 12 females, 23 children, three adults). In all, 15 of the ALL patients were specifically selected because they had
relapsed. All patients were studied by sequencing the mitochondrial D loop from nucleotides 16111–190 and in 37 patients; the same region was also studied by denaturing gradient gel
electrophoresis (DGGE). Mutations were found at diagnosis by sequencing in eight of the 22 patients (36%) with AML and 15 of the 26 patients (58%) with ALL. The difference in frequency
between AML and ALL was not significant (_P_=0.09, Fisher's exact test). Aberrant bands resulting from mutation were detected by DGGE with a sensitivity of 93% and a specificity of 98%.
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calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Monnat Jr RJ, Maxwell CL,
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Department of Haematology and Genetic Pathology, Flinders University and Flinders Medical Centre, Bedford Park, South Australia, Australia S A Grist, X-J Lu & A A Morley * HuaXi
Hospital, Sichuan University, Cheng Du, Sichuan, China X-J Lu Authors * S A Grist View author publications You can also search for this author inPubMed Google Scholar * X-J Lu View author
publications You can also search for this author inPubMed Google Scholar * A A Morley View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING
AUTHOR Correspondence to A A Morley. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Grist, S., Lu, XJ. & Morley, A. Mitochondrial mutations in acute
leukaemia. _Leukemia_ 18, 1313–1316 (2004). https://doi.org/10.1038/sj.leu.2403380 Download citation * Received: 16 November 2003 * Accepted: 16 March 2004 * Published: 06 May 2004 * Issue
Date: 01 July 2004 * DOI: https://doi.org/10.1038/sj.leu.2403380 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
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