ABSTRACT FLUID and solutes accumulate in the blastocyst just before implantation by transport mechanisms associated with the trophectoderm1–3. This structure is a simple squamous epithelium

that surrounds the embryo, and it is the first tissue to develop in the mammalian embryo4. We describe here electrophysiological experiments which demonstrate changes in transport functions

of this epithelium in the rabbit a few hours before, the expected time of implantation. At this time fluid is accumulating rapidly in the blastocoele5. The following results show that

between 6 and 7-d post-coitum (p.c.) a transtrophectodermal, rheogenic, amiloride-sensitive Na+ transport system develops. The term ‘rheogenic’ characterises non-neutral or

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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in

* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS INVERSE BLEBS OPERATE AS HYDRAULIC PUMPS DURING MOUSE BLASTOCYST

FORMATION Article 11 September 2024 ANALYSIS OF TWO LAYERED PERISTALTIC-CILIARY TRANSPORT OF JEFFREY FLUID AND IN VITRO PREIMPLANTATION EMBRYO DEVELOPMENT Article Open access 17 January 2024

KIDNEY EPITHELIAL CELLS ARE ACTIVE MECHANO-BIOLOGICAL FLUID PUMPS Article Open access 28 April 2022 REFERENCES * Biggers, J. D. & Borland, R. M. _A. Rev. Physiol._ 381, 95–119 (1976).

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Boston College, Chestnut Hill, Massachusetts, 02167 AUTHORS AND AFFILIATIONS * Department of Physiology and Laboratory of Human Reproduction and Reproductive Biology, Harvard Medical School,

45 Shattuck Street, Boston, Massachusetts, 02115 R. DOUGLAS POWERS, R. MICHAEL BORLAND & JOHN D. BIGGERS Authors * R. DOUGLAS POWERS View author publications You can also search for

this author inPubMed Google Scholar * R. MICHAEL BORLAND View author publications You can also search for this author inPubMed Google Scholar * JOHN D. BIGGERS View author publications You

can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE POWERS, R., BORLAND, R. & BIGGERS, J.

Amiloride-sensitive rheogenic Na+ transport in rabbit blastocyst. _Nature_ 270, 603–604 (1977). https://doi.org/10.1038/270603a0 Download citation * Received: 24 August 1977 * Accepted: 07

October 1977 * Issue Date: 15 December 1977 * DOI: https://doi.org/10.1038/270603a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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