ABSTRACT Administration of replication-deficient recombinant adenoviruses (Ad) designed as vectors for gene transfer to the airway tract of rats and monkeys has been associated with a

dose-dependent inflammatory process a few days after viral exposure. Among the cellular mechanisms possibly involved, we investigated the expression of intercellular adhesion molecule-1

(ICAM-1), which is known to be induced by parainfluenza, adenovirus type 5 and respiratory syncytial viruses in vitro. To test this hypothesis, an Ad type 5-derived replication-deficient

recombinant vector carrying the expression cassette for the cystic fibrosis gene (Ad.CFTR) was either incubated with A549 cells (a human-derived lung epithelial cell line) or instilled by

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DUAL INFECTIONS OF AIRWAY EPITHELIA Article Open access 24 June 2020 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Cystic Fibrosis Center, Azienda Ospedaliera Verona, Italy E Nicolis, A

Tamanini, P Melotti, R Rolfini & G Cabrini * Institute of General Pathology, University of Verona, Italy G Berton & MA Cassatella * IntroGene BV, Leiden, The Netherlands A Bout *

Transgene SA, Strasbourg, France A Pavirani Authors * E Nicolis View author publications You can also search for this author inPubMed Google Scholar * A Tamanini View author publications You

can also search for this author inPubMed Google Scholar * P Melotti View author publications You can also search for this author inPubMed Google Scholar * R Rolfini View author publications

You can also search for this author inPubMed Google Scholar * G Berton View author publications You can also search for this author inPubMed Google Scholar * MA Cassatella View author

publications You can also search for this author inPubMed Google Scholar * A Bout View author publications You can also search for this author inPubMed Google Scholar * A Pavirani View

author publications You can also search for this author inPubMed Google Scholar * G Cabrini View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Nicolis, E., Tamanini, A., Melotti, P. _et al._ ICAM-1 induction in respiratory cells exposed to a

replication-deficient recombinant adenovirus in vitro and in vivo. _Gene Ther_ 5, 131–136 (1998). https://doi.org/10.1038/sj.gt.3300558 Download citation * Received: 26 April 1996 *

Accepted: 26 August 1997 * Published: 04 March 1998 * Issue Date: 01 January 1998 * DOI: https://doi.org/10.1038/sj.gt.3300558 SHARE THIS ARTICLE Anyone you share the following link with

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content-sharing initiative KEYWORDS * ICAM-1 * adenovirus * gene therapy * cystic fibrosis