ABSTRACT Major depressive disorder (MDD) constitutes a major public health problem worldwide and affects women twice as frequently as men. Previous linkage studies have identified a 451 kb

region of 2q33–35 that exhibited significant evidence of linkage to Mood Disorders among women (but not men) from families with recurrent, early-onset MDD (RE-MDD), a severe and strongly

familial subtype of MDD. This 451 kb region includes _CREB1_, an attractive susceptibility gene for MDD and related disorders. Sequence variations in the _CREB1_ promoter and intron 8 have

been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying _CREB1_ as a sex-limited susceptibility gene for unipolar Mood Disorders.

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GENETIC ARCHITECTURE OF DEPRESSION Article Open access 18 June 2020 THE GENETIC BASIS OF MAJOR DEPRESSIVE DISORDER Article Open access 26 January 2023 THE GENETICS OF SEVERE DEPRESSION

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  Google Scholar  Download references ACKNOWLEDGEMENTS The previous contributions of the research staff of this project, and the families who participated, are gratefully acknowledged. This

work was supported by research project Grants MH48969 and MH60866 (GSZ). Automated DNA sequencing was performed by the Genomics and Proteomics Core Laboratories of the University of

Pittsburgh. Some of the results of this study were obtained using S.A.G.E., supported by US Public Health Service Resource Grant 1-P41-RR03655. GSZ was the recipient of Independent Scientist

Award MH00540 from the National Institute of Mental Health. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh,

PA, USA G S Zubenko, H B Hughes III, J S Stiffler, A Brechbiel, W N Zubenko & M L Marazita * Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of

Pittsburgh, Pittsburgh, PA, USA B S Maher & M L Marazita * Department of Biological Sciences, Mellon College of Science, Carnegie-Mellon University, Pittsburgh, PA, USA G S Zubenko *

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA M L Marazita Authors * G S Zubenko View author publications You can also search

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ARTICLE CITE THIS ARTICLE Zubenko, G., Hughes, H., Stiffler, J. _et al._ Sequence variations in _CREB1_ cosegregate with depressive disorders in women. _Mol Psychiatry_ 8, 611–618 (2003).

https://doi.org/10.1038/sj.mp.4001354 Download citation * Received: 12 February 2003 * Revised: 06 March 2003 * Accepted: 11 March 2003 * Published: 08 July 2003 * Issue Date: 01 June 2003 *

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * genetics * _CREB1_ * depression * sex-specific * women