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ABSTRACT The _MPZL1/PZR_ gene has been mapped to 1q23.3, located in close proximity to a recognized schizophrenia susceptibility locus. Recently, the _MPZL1/PZR_ gene has been found to be
significantly upregulated in schizophrenia brain tissue and to play an important role in cell signaling, thus indicating that _MPZL1/PZR_ could be a potential schizophrenia marker. To test
this hypothesis, we selected three single nucleotide polymorphisms (SNPs) for genotyping in 523 Han Chinese trios. We found that two individual SNPs were significant at the Bonferroni's
corrected significance level _P_<0.017: rs3767444 (_χ_2=6.299, _P_=0.0121) and rs2051656 (_χ_2=9.856, _P_=0.0017). Haplotype transmission/disequilibrium tests revealed a significant
association with the disease (global _P_-value=1.064 × 10−6), but no specific transmission distortions. Thus, we propose that the _MPZL1/PZR_ gene may be important in the predisposition to
schizophrenia among Han Chinese. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
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our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS GENOME WIDE ASSOCIATION STUDY IDENTIFIES FOUR LOCI FOR EARLY ONSET SCHIZOPHRENIA Article Open access 27 April 2021
GENOME-WIDE ASSOCIATION IDENTIFIES THE FIRST RISK LOCI FOR PSYCHOSIS IN ALZHEIMER DISEASE Article 10 June 2021 A MISSENSE VARIANT IN _NDUFA6_ CONFERS SCHIZOPHRENIA RISK BY AFFECTING YY1
BINDING AND _NAGA_ EXPRESSION Article 30 April 2021 REFERENCES * Harrison PJ, Owen MJ . Genes for schizophrenia? Recent findings and their pathophysiological implications. _Lancet_ 2003;
361: 417–419. Article CAS Google Scholar * Hovatta I, Varilo T, Suvisaari J, Terwilliger JD, Ollikainen V, Arajarvi R _et al_. A genomewide screen for schizophrenia genes in an isolated
Finnish subpopulation, suggesting multiple susceptibility loci. _Am J Hum Genet_ 1999; 65: 1114–1124. Article CAS Google Scholar * Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG,
Bassett AS . Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21–q22. _Science_ 2000; 288: 678–682. Article CAS Google Scholar * Gurling HM, Kalsi G,
Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS _et al_. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2,
5q33.2, and 8p21–22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3–24 and 20q12.1–11.23. _Am J Hum Genet_ 2001; 68: 661–673. Article CAS Google Scholar *
Brzustowicz LM, Hayter JE, Hodgkinson KA, Chow EW, Bassett AS . Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22. _Hum Hered_ 2002; 54: 199–209. Article CAS Google
Scholar * Zhao ZJ, Zhao R . Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2. _J Biol Chem_ 1998; 273: 29367–29372.
Article CAS Google Scholar * Zhao R, Zhao ZJ . Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.
_J Biol Chem_ 2000; 275: 5453–5459. Article CAS Google Scholar * Zhao R, Zhao ZJ . Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs.
_Biochem Biophys Res Commun_ 2003; 303: 1028–1033. Article CAS Google Scholar * Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, Jones PB _et al_. Oligodendrocyte dysfunction in
schizophrenia and bipolar disorder. _Lancet_ 2003; 362: 798–805. Article CAS Google Scholar * Little J, Bradley L, Bray MS, Clyne M, Dorman J, Ellsworth DL _et al_. Reporting, appraising,
and integrating data on genotype prevalence and gene–disease associations. _Am J Epidemiol_ 2002; 156: 300–310. Article Google Scholar * Colhoun HM, McKeigue PM, Davey Smith G . Problems
of reporting genetic associations with complex outcomes. _Lancet_ 2003; 361: 865–872. Article Google Scholar * Spitzer RL, Williams JB, Gibbon M, First MB . The structured clinical
interview for DSM-III-R (SCID). I: history, rationale, and description. _Arch Gen Psychiatr_ 1992; 49: 624–629. Article CAS Google Scholar * Greenwood TA, Alexander M, Keck PE, McElroy S,
Sadovnick AD, Remick RA . Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. _Am J Med Genet_ 2001; 105: 145–151. Article CAS Google Scholar *
Germer S, Holland MJ, Higuchi R . High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR. _Genome Res_ 2001; 10: 258–266. Article Google Scholar * Tang JX,
Zhou J, Fan JB, Li XW, Shi YY, Gu NF _et al_. Family-based association study of DTNBP1 in 6p22.3 and schizophrenia. _Mol Psychiatr_ 2003; 8: 717–718. Article CAS Google Scholar * Sham
PC, Curtis D . An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. _Ann Hum Genet_ 1995; 59: 323–336. Article CAS Google Scholar * Clayton D . A
generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. _Am J Hum Genet_ 1999; 65: 1170–1177. Article CAS Google Scholar * Zapata C, Carollo C,
Rodriguez S . Sampling variance and distribution of the _D′_measure of overall gametic disequilibrium between multiallelic loci. _Ann Hum Genet_ 2001; 65: 395–406. Article CAS Google
Scholar * Sham PC, Curtis D . Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. _Ann Hum Genet_ 1995; 59: 97–105. Article CAS Google Scholar *
Hayasaka K, Nanao K, Tahara M, Sato W, Takada G, Miura M _et al_. Isolation and sequence determination of cDNA encoding the major structural protein of human peripheral myelin. _Biochem
Biophys Res Commun_ 1991; 180: 515–518. Article CAS Google Scholar * Pham-Dinh D, Fourbil Y, Blanquet F, Mattei MG, Roeckel N, Latour P _et al_. The major peripheral myelin protein zero
gene: structure and localization in the cluster of Fc gamma receptor genes on human chromosome 1q21.3-q23. _Hum Mol Genet_ 1993; 2: 2051–2054. Article CAS Google Scholar * Hayasaka K,
Himoro M, Sato W, Takada G, Uyemura K, Shimizu N _et al_. Charcot-Marie-Tooth neuropathy type 1B is associated with mutations of the myelin P0 gene. _Nat Genet_ 1993; 5: 31–34. Article CAS
Google Scholar * Hayasaka K, Himoro M, Sawaishi Y, Nanao K, Takahashi T, Takada G _et al_. _De novo_ mutation of the myelin P0 gene in Dejerine-Sottas disease (hereditary motor and
sensory neuropathy type III). _Nat Genet_ 1993; 5: 266–268. Article CAS Google Scholar * Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD _et al_. Genome-wide expression analysis
reveals dysregulation of myelination-related genes in chronic schizophrenia. _Proc Natl Acad Sci USA_ 2001; 98: 4746–4747. Article CAS Google Scholar Download references ACKNOWLEDGEMENTS
This work was supported by grants from the National Natural Science Foundation of China, the National 973 and 863 Programs the Ministry of Education, PRC and the Shanghai Municipal
Commission for Science and Technology. We thank NIH intramural support and the editorial assistance of the NCI, CCR Fellows Editorial Board. AUTHOR INFORMATION Author notes * G He and X Liu:
These authors contributed equally to this work. AUTHORS AND AFFILIATIONS * Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, PR China G He, X Liu, W Qin, Q Chen,
Y Yang & J Zhou * Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China G He, X Liu, W Qin, Q Chen, X Wang, Y
Yang, J Zhou & L He * NHGG, Bio-X, Shanghai Jiao Tong University, Shanghai, PR China X Wang & L He * Shanghai Institute of Mental Health, Shanghai, PR China Y Xu, N Gu & G Feng *
Changchun Kaixuan Hospital, Changchun, PR China H Sang * Wuhu No.4 People's Hospital, Wuhu, PR China P Wang Authors * G He View author publications You can also search for this author
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inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to G He. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE He, G., Liu, X., Qin, W. _et al._
_MPZL1/PZR_, a novel candidate predisposing schizophrenia in Han Chinese. _Mol Psychiatry_ 11, 748–751 (2006). https://doi.org/10.1038/sj.mp.4001841 Download citation * Received: 25 March
2005 * Revised: 04 April 2006 * Accepted: 07 April 2006 * Published: 09 May 2006 * Issue Date: 01 August 2006 * DOI: https://doi.org/10.1038/sj.mp.4001841 SHARE THIS ARTICLE Anyone you share
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Nature SharedIt content-sharing initiative KEYWORDS * schizophrenia * Han Chinese * family trios * _MPZL1/PZR_ * TDT