Mpzl1/pzr, a novel candidate predisposing schizophrenia in han chinese

Mpzl1/pzr, a novel candidate predisposing schizophrenia in han chinese

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ABSTRACT The _MPZL1/PZR_ gene has been mapped to 1q23.3, located in close proximity to a recognized schizophrenia susceptibility locus. Recently, the _MPZL1/PZR_ gene has been found to be


significantly upregulated in schizophrenia brain tissue and to play an important role in cell signaling, thus indicating that _MPZL1/PZR_ could be a potential schizophrenia marker. To test


this hypothesis, we selected three single nucleotide polymorphisms (SNPs) for genotyping in 523 Han Chinese trios. We found that two individual SNPs were significant at the Bonferroni's


corrected significance level _P_<0.017: rs3767444 (_χ_2=6.299, _P_=0.0121) and rs2051656 (_χ_2=9.856, _P_=0.0017). Haplotype transmission/disequilibrium tests revealed a significant


association with the disease (global _P_-value=1.064 × 10−6), but no specific transmission distortions. Thus, we propose that the _MPZL1/PZR_ gene may be important in the predisposition to


schizophrenia among Han Chinese. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your


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our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS GENOME WIDE ASSOCIATION STUDY IDENTIFIES FOUR LOCI FOR EARLY ONSET SCHIZOPHRENIA Article Open access 27 April 2021


GENOME-WIDE ASSOCIATION IDENTIFIES THE FIRST RISK LOCI FOR PSYCHOSIS IN ALZHEIMER DISEASE Article 10 June 2021 A MISSENSE VARIANT IN _NDUFA6_ CONFERS SCHIZOPHRENIA RISK BY AFFECTING YY1


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This work was supported by grants from the National Natural Science Foundation of China, the National 973 and 863 Programs the Ministry of Education, PRC and the Shanghai Municipal


Commission for Science and Technology. We thank NIH intramural support and the editorial assistance of the NCI, CCR Fellows Editorial Board. AUTHOR INFORMATION Author notes * G He and X Liu:


These authors contributed equally to this work. AUTHORS AND AFFILIATIONS * Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, PR China G He, X Liu, W Qin, Q Chen, 


Y Yang & J Zhou * Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China G He, X Liu, W Qin, Q Chen, X Wang, Y


Yang, J Zhou & L He * NHGG, Bio-X, Shanghai Jiao Tong University, Shanghai, PR China X Wang & L He * Shanghai Institute of Mental Health, Shanghai, PR China Y Xu, N Gu & G Feng *


Changchun Kaixuan Hospital, Changchun, PR China H Sang * Wuhu No.4 People's Hospital, Wuhu, PR China P Wang Authors * G He View author publications You can also search for this author


inPubMed Google Scholar * X Liu View author publications You can also search for this author inPubMed Google Scholar * W Qin View author publications You can also search for this author


inPubMed Google Scholar * Q Chen View author publications You can also search for this author inPubMed Google Scholar * X Wang View author publications You can also search for this author


inPubMed Google Scholar * Y Yang View author publications You can also search for this author inPubMed Google Scholar * J Zhou View author publications You can also search for this author


inPubMed Google Scholar * Y Xu View author publications You can also search for this author inPubMed Google Scholar * N Gu View author publications You can also search for this author


inPubMed Google Scholar * G Feng View author publications You can also search for this author inPubMed Google Scholar * H Sang View author publications You can also search for this author


inPubMed Google Scholar * P Wang View author publications You can also search for this author inPubMed Google Scholar * L He View author publications You can also search for this author


inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to G He. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE He, G., Liu, X., Qin, W. _et al._


_MPZL1/PZR_, a novel candidate predisposing schizophrenia in Han Chinese. _Mol Psychiatry_ 11, 748–751 (2006). https://doi.org/10.1038/sj.mp.4001841 Download citation * Received: 25 March


2005 * Revised: 04 April 2006 * Accepted: 07 April 2006 * Published: 09 May 2006 * Issue Date: 01 August 2006 * DOI: https://doi.org/10.1038/sj.mp.4001841 SHARE THIS ARTICLE Anyone you share


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Nature SharedIt content-sharing initiative KEYWORDS * schizophrenia * Han Chinese * family trios * _MPZL1/PZR_ * TDT