ABSTRACT The _MPZL1/PZR_ gene has been mapped to 1q23.3, located in close proximity to a recognized schizophrenia susceptibility locus. Recently, the _MPZL1/PZR_ gene has been found to be

significantly upregulated in schizophrenia brain tissue and to play an important role in cell signaling, thus indicating that _MPZL1/PZR_ could be a potential schizophrenia marker. To test

this hypothesis, we selected three single nucleotide polymorphisms (SNPs) for genotyping in 523 Han Chinese trios. We found that two individual SNPs were significant at the Bonferroni's

corrected significance level _P_<0.017: rs3767444 (_χ_2=6.299, _P_=0.0121) and rs2051656 (_χ_2=9.856, _P_=0.0017). Haplotype transmission/disequilibrium tests revealed a significant

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This work was supported by grants from the National Natural Science Foundation of China, the National 973 and 863 Programs the Ministry of Education, PRC and the Shanghai Municipal

Commission for Science and Technology. We thank NIH intramural support and the editorial assistance of the NCI, CCR Fellows Editorial Board. AUTHOR INFORMATION Author notes * G He and X Liu:

These authors contributed equally to this work. AUTHORS AND AFFILIATIONS * Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, PR China G He, X Liu, W Qin, Q Chen, 

Y Yang & J Zhou * Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China G He, X Liu, W Qin, Q Chen, X Wang, Y

Yang, J Zhou & L He * NHGG, Bio-X, Shanghai Jiao Tong University, Shanghai, PR China X Wang & L He * Shanghai Institute of Mental Health, Shanghai, PR China Y Xu, N Gu & G Feng *

Changchun Kaixuan Hospital, Changchun, PR China H Sang * Wuhu No.4 People's Hospital, Wuhu, PR China P Wang Authors * G He View author publications You can also search for this author

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_MPZL1/PZR_, a novel candidate predisposing schizophrenia in Han Chinese. _Mol Psychiatry_ 11, 748–751 (2006). https://doi.org/10.1038/sj.mp.4001841 Download citation * Received: 25 March

2005 * Revised: 04 April 2006 * Accepted: 07 April 2006 * Published: 09 May 2006 * Issue Date: 01 August 2006 * DOI: https://doi.org/10.1038/sj.mp.4001841 SHARE THIS ARTICLE Anyone you share

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Nature SharedIt content-sharing initiative KEYWORDS * schizophrenia * Han Chinese * family trios * _MPZL1/PZR_ * TDT