ABSTRACT Abnormal expression of the _N_-Methyl-_D_-Aspartate (NMDA) receptor and its interacting molecules of the postsynaptic density (PSD) are thought to be involved in the pathophysiology

of schizophrenia. Frontal regions of neocortex including dorsolateral prefrontal (DLPFC) and anterior cingulate cortex (ACC) are essential for cognitive and behavioral functions that are

affected in schizophrenia. In this study, we have measured protein expression of two alternatively spliced isoforms of the NR1 subunit (NR1C2 and NR1C2′) as well as expression of the NR2A–D

subunits of the NMDA receptor in DLPFC and ACC in post-mortem samples from elderly schizophrenic patients and a comparison group. We found significantly increased expression of NR1C2′ but

PSD-93 in ACC and DLPFC at both transcriptional and translational levels. We found significant changes in the expression of NF-L in DLPFC, and PSD-95 and PSD-93 in ACC; increased transcript

expression was associated with decreased protein expression, suggesting abnormal translation and/or accelerated protein degradation of these molecules in schizophrenia. Our findings suggest

abnormal regional processing of the NMDA receptor and its associated PSD molecules, possibly involving transcription, translation, trafficking and protein stability in cortical areas in

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Scholar  Download references ACKNOWLEDGEMENTS This work was supported by MH53327 (Dr Meador-Woodruff) and MH45212 and MH064673 (Dr Haroutunian). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA L V Kristiansen, M Beneyto & J H Meador-Woodruff * Department of

Psychiatry, Mount Sinai School of Medicine, New York, NY, USA V Haroutunian Authors * L V Kristiansen View author publications You can also search for this author inPubMed Google Scholar * M

Beneyto View author publications You can also search for this author inPubMed Google Scholar * V Haroutunian View author publications You can also search for this author inPubMed Google

Scholar * J H Meador-Woodruff View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to L V Kristiansen. RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kristiansen, L., Beneyto, M., Haroutunian, V. _et al._ Changes in NMDA receptor subunits and interacting PSD

proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia. _Mol Psychiatry_ 11, 737–747 (2006).

https://doi.org/10.1038/sj.mp.4001844 Download citation * Received: 13 October 2005 * Accepted: 17 April 2006 * Published: 16 May 2006 * Issue Date: 01 August 2006 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * glutamate * translation * _in situ_ hybridization *

postmortem * Western blotting * cortex