ABSTRACT We have analysed the distribution of CAG and adjacent polymorphic CCG repeats in the _HUNTINGTIN_ gene in 28 clinically diagnosed unrelated Huntington's disease (HD) patients

and in normal individuals belonging to different ethnic groups of India. The range of expanded CAG repeats in HD patients varied from 41 to 56 repeats, whereas in normal individuals this

number varied between 11 and 31 repeats. We identified six CCG alleles from a total of 380 normal chromosomes that were pooled across different ethnic populations of India. There were two

predominant alleles: (CCG)7 (72.6%) and (CCG)10 (20%). We report here for the first time one four-repeat CCG allele which has not been found in any population so far. We found 30 haplotypes

these populations. SIMILAR CONTENT BEING VIEWED BY OTHERS FREQUENCY OF THE LOSS OF CAA INTERRUPTION IN THE _HTT_ CAG TRACT AND IMPLICATIONS FOR HUNTINGTON DISEASE IN THE REDUCED PENETRANCE

RANGE Article Open access 03 August 2020 HIGH FREQUENCY OF INTERMEDIARY ALLELES IN THE _HTT_ GENE IN NORTHERN SWEDEN - THE SWEDISH HUNTINGTIN ALLELES AND PHENOTYPE (SHAPE) STUDY Article Open

access 17 June 2020 TRACING THE MUTATED _HTT_ AND HAPLOTYPE OF THE AFRICAN ANCESTOR WHO SPREAD HUNTINGTON DISEASE INTO THE MIDDLE EAST Article 14 July 2020 ARTICLE PDF AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Srimanta Pramanik, Priyadarshi Basu & Nitai P Bhattacharyya * Bangur

Institute of Neurology, Calcutta Prasanta K Gangopadhaya, Shyamal K Das & Bibek K Maity * Advanced Diagnostic Centre, Ranchi Krishna K Sinha, D K Jha & S Sinha * Calcutta Medical

College, Subhas C Mukherjee * Indian Institute of Chemical Biology, Sushanta Roychoudhuri * Indian Statistical Institute, Calcutta, India Partha P Majumder Authors * Srimanta Pramanik View

author publications You can also search for this author inPubMed Google Scholar * Priyadarshi Basu View author publications You can also search for this author inPubMed Google Scholar *

Prasanta K Gangopadhaya View author publications You can also search for this author inPubMed Google Scholar * Krishna K Sinha View author publications You can also search for this author

inPubMed Google Scholar * D K Jha View author publications You can also search for this author inPubMed Google Scholar * S Sinha View author publications You can also search for this author

inPubMed Google Scholar * Shyamal K Das View author publications You can also search for this author inPubMed Google Scholar * Bibek K Maity View author publications You can also search for

this author inPubMed Google Scholar * Subhas C Mukherjee View author publications You can also search for this author inPubMed Google Scholar * Sushanta Roychoudhuri View author publications

You can also search for this author inPubMed Google Scholar * Partha P Majumder View author publications You can also search for this author inPubMed Google Scholar * Nitai P Bhattacharyya

View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Nitai P Bhattacharyya. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Pramanik, S., Basu, P., Gangopadhaya, P. _et al._ Analysis of CAG and CCG repeats in _HUNTINGTIN_ gene among HD patients and normal

populations of India. _Eur J Hum Genet_ 8, 678–682 (2000). https://doi.org/10.1038/sj.ejhg.5200515 Download citation * Received: 24 December 1999 * Revised: 13 April 2000 * Accepted: 27

April 2000 * Published: 31 August 2000 * Issue Date: 01 September 2000 * DOI: https://doi.org/10.1038/sj.ejhg.5200515 SHARE THIS ARTICLE Anyone you share the following link with will be able

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initiative KEYWORDS * Huntington's disease * Indian populations * haplotype