ABSTRACT The cytotoxicity of two compounds described as anti-angiogenic, the isoflavone genistein and the oestrogen metabolite 2-methoxyestradiol, has been studied in different human tumour

cell lines. Since the degradation of the extracellular matrix is one of the essential steps in angiogenesis, the potential modulatory effects of both compounds on the proteolytic balance in

media conditioned by different human tumour cells have been also investigated. The IC50 values for 2-methoxyestradiol were lower than those for genistein on all the cell lines tested. In all

the cell lines expressing measurable amounts of active enzymes, genistein induced a shift towards antiproteolysis in both matrix metalloproteinase/tissue inhibitor of metalloproteinase and

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HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS AND EXHIBITS ANTI-ANGIOGENIC EFFECTS IN VIVO Article Open access 06 July 2020 ARTICLE PDF CHANGE HISTORY * _ 16 NOVEMBER 2011 This paper was modified

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embryo. _Cancer Res_ 53: 1397–1402. CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratorio de Bioquímica y Biología Molecular, Facultad de

Ciencias, Universidad de Málag, Málaga, E-29071, Spain I Fajardo, A R Quesada, I Núñez de Castro, F Sánchez-Jiménez & M Á Medina Authors * I Fajardo View author publications You can

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permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fajardo, I., Quesada, A., Castro, I. _et al._ A comparative study of the effects of genistein and 2-methoxyestradiol on the proteolytic

balance and tumour cell proliferation. _Br J Cancer_ 80, 17–24 (1999). https://doi.org/10.1038/sj.bjc.6690315 Download citation * Received: 13 May 1998 * Revised: 04 August 1998 * Accepted:

06 November 1998 * Published: 26 March 1999 * Issue Date: 01 April 1999 * DOI: https://doi.org/10.1038/sj.bjc.6690315 SHARE THIS ARTICLE Anyone you share the following link with will be able

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initiative KEYWORDS * angiogenesis * urokinase * plasminogen activator inhibitor * matrix metalloproteinase * tissue inhibitor of matrix metalloproteinase