ABSTRACT The Third National Health and Nutrition Examination Survey (NHANES-III) of the Centers for Disease Control and Prevention (CDC) recorded data on the urinary concentrations of 12

chemicals (analytes), which were either pesticides or their metabolites, that represent exposure to certain pesticides, in urine samples collected from 1988 to 1994 from a cohort of 978

volunteer subjects, aged 20–59 years. We have used each subject's urinary creatinine concentration and their individual daily creatinine excretion rate (g/day) computed from their age,

gender, height and weight, to estimate their daily excretion rate in _μ_g analyte/kg/day. We discuss the mechanisms of excretion of the analytes and certain assumptions needed to compute the

pesticides. A Johnson SB distribution (four-parameter lognormal) was fit to these data to estimate the national distribution of exclusive exposures to these 12 parent compounds. Only three

such pesticides had a few predicted values above their RfD (lindane 1.6%; 2,4-dichlorophenol 1.3%; chlorpyrifos 0.02%). Given the possibility of a subject's dietary intake of a

pesticide's metabolites incorporated into treated food, our results show that few, if any, individuals in the general US population aged 20–59 years and not employed in pesticide

application were likely to have exceeded the USEPA RfD for these parent compounds during the years studied. Access through your institution Buy or subscribe This is a preview of subscription

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CONCENTRATIONS OF PHTHALATES AND SOME OF THEIR REPLACEMENTS IN CHILDREN IN THE PROJECT VIVA COHORT Article 23 December 2022 DETERMINANTS OF URINARY DIALKYL PHOSPHATE METABOLITES IN MIDLIFE

WOMEN: THE STUDY OF WOMEN’S HEALTH ACROSS THE NATION MULTI-POLLUTANT STUDY (SWAN-MPS) Article 08 May 2024 BAYESIAN INFERENCE OF CHEMICAL EXPOSURES FROM NHANES URINE BIOMONITORING DATA

Article 17 August 2022 NOTES * where 1.93=(1440 min/day)(1000 _μ_g/mg)/(72 year-kg/[mg/dl-ml/min-1.73 m2])(3600 cm-kg/m4)0.5 (1.73 m2)(100 ml/dl) ABBREVIATIONS * 1NAP: 1-naphthol * 2NAP:

2-naphthol * 24D: 2,4-dichlorophenoxyacetic acid * 24DB: 2,4-dichlorophenoxybutyric acid * 24DCP: 2,4-dichlorophenol * 245TCP: 2,4,5-trichlorophenol * 246TCP: 2,4,6-trichlorophenol * 25DCP:

2,5-dichlorophenol * 4NP: 4-nitrophenol * BSA: body surface area * CDC: Centers for disease control and prevention * CFP: carbofuranphenol * Cn: creatinine * CnCl: creatinine clearance *

EPN: O-ethyl O-_p_-nitrophenyl phenylphosphonothioate * IPP: 2-isopropoxyphenol * MDL: minimum detectable level * MLE: method of maximum likelihood estimation * NCEH: National Center for

Environmental Health * NCHS: National Center for Health Statistics * NHANES-III: The Third National Health and Nutrition Examination Survey * PCP: pentachlorophenol * RfD: reference dose *

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Environ Epidemiol_ 2003: 13: 187–202. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported under USEPA Contract 401893671 - DAI to Temple University.

Jennifer Weil, MD, of Temple University and David J. Miller, Carol Christensen and Peter Egeghy of US EPA provided technical review. The views expressed are those of the authors, and they do

not represent US EPA policy. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Temple University, Philadelphia, PA, USA David T Mage, Gauthami Gondy & Woollcott Smith * US Environmental

Protection Agency, Arlington, VA, USA Ruth H Allen * Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA, USA Dana B Barr & Larry L Needham

Authors * David T Mage View author publications You can also search for this author inPubMed Google Scholar * Ruth H Allen View author publications You can also search for this author

inPubMed Google Scholar * Gauthami Gondy View author publications You can also search for this author inPubMed Google Scholar * Woollcott Smith View author publications You can also search

for this author inPubMed Google Scholar * Dana B Barr View author publications You can also search for this author inPubMed Google Scholar * Larry L Needham View author publications You can

also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to David T Mage. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Mage, D., Allen, R., Gondy, G. _et al._ Estimating pesticide dose from urinary pesticide concentration data by creatinine correction in the Third National Health and Nutrition Examination

Survey (NHANES-III). _J Expo Sci Environ Epidemiol_ 14, 457–465 (2004). https://doi.org/10.1038/sj.jea.7500343 Download citation * Published: 15 September 2004 * Issue Date: 01 November 2004

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not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * _creatinine correction_ * _S_ _B_ _ model_ *

_reference dose_ * _transport maximum_ * _NHANES-III_.