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ABSTRACT Simultaneous measurement of neutrophil migration, phagocytic activity, candidacidal and bactericidal activity were made during quadruple chemotherapy of advanced Hodgkin's
disease (HD). Measurements were also made in normal individuals, hospital patients not on chemotherapy, untreated patients with advanced HD and patients off chemotherapy for over a year.
Neutrophil migratory activity was usually normal in untreated HD patients and those on chemotherapy, but less than 20% of all tests showed depressed values, some of which were corrected by
plasma. Similar results were found with neutrophil phagocytosis. Abnormalities in these functions were found in both early and late cycles, but there was a tendency for migration to
deteriorate during later chemotherapy cycles. Neutrophil candidacidal and bactericidal activity were frequently depressed in patients on treatment and there was deterioration in candidacidal
activity during the chemotherapy cycle. These abnormalities of killing activity were frequently corrected in control plasma. Neutrophil function is normal in most patients with advanced HD
and in patients in remission. In a minority of patients on treatment there are marked functional defects, especially in killing activity. These defects are partly cell-associated and partly
plasma-related. Susceptibility to infection during chemotherapy of HD may be partly due to defective neutrophil function. Access through your institution Buy or subscribe This is a preview
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February 2023 Authors * M Gandossini View author publications You can also search for this author inPubMed Google Scholar * R L Souhami View author publications You can also search for this
author inPubMed Google Scholar * J Babbage View author publications You can also search for this author inPubMed Google Scholar * I E Addison View author publications You can also search for
this author inPubMed Google Scholar * A L Johnson View author publications You can also search for this author inPubMed Google Scholar * M C Berenbaum View author publications You can also
search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Gandossini, M., Souhami, R., Babbage, J. _et al._
Neutrophil function during chemotherapy for Hodgkin's disease. _Br J Cancer_ 44, 863–871 (1981). https://doi.org/10.1038/bjc.1981.285 Download citation * Issue Date: 01 December 1981 *
DOI: https://doi.org/10.1038/bjc.1981.285 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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