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ABSTRACT A retrospective analysis was performed upon 175 patients with Non-Hodgkin's Lymphoma involving the gastrointestinal tract and entered into BNLI trials and studies between
1974-1988. Malignant histiocytosis of the intestine (MHI), which was present in 16 patients, was associated with a survival of less than 25% at 18 months, and probably accounted for the poor
survival of patients with jejunal involvement. Histopathological evidence of tumour origin from mucosa-associated lymphoid tissue (MALT) was found in 50% of patients with gastric
involvement and in 27% of those with intestinal involvement. The overall survival of the series as a whole was 44% at 10 years. Multivariate analysis identified evidence of tumour origin
from MALT as the only factor to attain prognostic significance in patients with gastric involvement, and clinical stage and the presence of MHI as the only factors to attain prognostic
significance in patients with intestinal involvement. It is suggested that there is a need for a large multicentre prospective study of GIT lymphoma. Access through your institution Buy or
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GUIDELINES Article Open access 05 June 2024 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Clinical Haematology, East Birmingham Hospital, UK JE Morton Authors * JE Morton View
author publications You can also search for this author inPubMed Google Scholar * MJ Leyland View author publications You can also search for this author inPubMed Google Scholar * G Vaughan
Hudson View author publications You can also search for this author inPubMed Google Scholar * B Vaughan Hudson View author publications You can also search for this author inPubMed Google
Scholar * L Anderson View author publications You can also search for this author inPubMed Google Scholar * MH Bennett View author publications You can also search for this author inPubMed
Google Scholar * KA MacLennan View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE
THIS ARTICLE Morton, J., Leyland, M., Vaughan Hudson, G. _et al._ Primary gastrointestinal non-Hodgkin's lymphoma: a review of 175 British National Lymphoma Investigation cases. _Br J
Cancer_ 67, 776–782 (1993). https://doi.org/10.1038/bjc.1993.141 Download citation * Issue Date: 01 April 1993 * DOI: https://doi.org/10.1038/bjc.1993.141 SHARE THIS ARTICLE Anyone you share
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